高同型半胱氨酸血症与高血压病发病机制的研究进展  

Research Progress of Hyperhomocysteinemia and Pathogenesis of Hypertension

作　　者：何莉[1,2] 陈明[1,2] 

机构地区：[1]重庆医科大学 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《心血管病学进展》2015年第3期283-287,共5页Advances in Cardiovascular Diseases

摘　　要：高血压病在我国患病率极高,同时它也是各类慢性非传染性公众疾病中最为常见,对国家卫生系统负担最重,对患者生活质量及生存率影响极大的疾病之一。既往关于高血压病发病危险因素的研究已经甚多,但仍然没有直接有力的证据表明众多危险因素与高血压病发病机制之间有直接的量化关系。同型半胱氨酸是人体内一种非必需氨基酸,当它在人体内质量浓度超过10μmol/L时,诊断为高同型半胱氨酸血症。大量的临床研究表明高同型半胱氨酸血症与高血压病的发生发展有着密不可分的关系。现对高同型半胱氨酸血症与高血压病发病机制的研究进展进行综述。The prevalence of hypertension in China is high.It is one of the most commonly seen chronic non-infectious disease in so-ciety.Therefore, it is an important target in the national healthcare system.While there is extensive research regarding the risk factors of hy-pertension, the factors that directly influence hypertension have not been found.Homocysteine is a nonessential amino acid in human body. When the concentration of homocysteine is greater than 10 μmol/L, a patient is diagnosed with hyperhomocysteinemia.Numerous clinical studies show that there is an inseparable relationship between the occurrence and development of hyperhomocysteinemia in patients with es-sential hypertension.This article reviews the recent progress in research into the relationship between hyperhomocysteinemia and hyperten-sion.

关 键 词：高血压 高同型半胱氨酸血症 硫化氢机制 

分 类 号：R544.1[医药卫生—心血管疾病] R589[医药卫生—内科学]