生物标志物对急性冠状动脉综合征的诊断价值研究进展  

Progress in Identifying the Diagnostic Value of Biomarkers to Acute Coronary Syndrome

作　　者：张琼[1,2] 邢艳秋[3] 

机构地区：[1]山东省医学科学院基础医学研究所,山东济南250062 [2]济南大学山东省医学科学院医学与生命科学学院,山东济南250062 [3]山东大学齐鲁医院,山东济南250012

出　　处：《心血管病学进展》2015年第3期328-331,共4页Advances in Cardiovascular Diseases

摘　　要：急性冠状动脉综合征(ACS)是以冠状动脉粥样硬化斑块破裂或糜烂,继发完全或不完全闭塞性血栓形成为病理基础的一组临床综合征,它是包括不稳定型心绞痛、非ST段抬高型心肌梗死和ST段抬高型心肌梗死的一系列临床病征。冠状动脉斑块的炎症是导致斑块不稳定,继而诱发ACS的主要因素,其间伴有炎症细胞因子释放,凝血系统激活和血栓形成,心肌细胞坏死及心室压力的改变等。快速而准确地诊断ACS可在早期识别患者并及时给予干预措施,有助于降低不良事件的发生率。现就ACS各病理过程所涉及的研究较多的生物标志物进行分类表述,以期从多方面了解ACS并比较各生物标志物对其的诊断价值。Acute coronary syndrome （ ACS） is a clinical syndrome for which the pathological basis is a coronary atherosclerotic plaque rupture or erosion, with a secondary complete or incomplete thrombotic occlusion, which also may include a series of clinical symptoms in-cluding unstable angina, non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction.Coronary plaque inflammation is a major factor leading to the plaque instability that causes ACS.The rapid and accurate diagnosis of ACS, combined with timely intervention helps reduce the incidence of adverse events in patients.This review examines the biomarkers involved in the various pathological processes of ACS in order to understand and compare the diagnostic value of those biomarkers in the treatment of ACS.

关 键 词：急性冠状动脉综合征 心脏生物标志物 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]