微小气候疗法对2型糖尿病患者白细胞CD_(11b)/CD_(18)表达的影响  

Influence of microclimatotherapy on hemameba CD_(11b)/CD_(18) expression of type 2 diabetic patients

作　　者：汪涛[1] 陈杰[1] 单守勤[1] 周国清[1] 

机构地区：[1]济南军区青岛第一疗养院第一疗养区,266071

出　　处：《中国疗养医学》2015年第6期561-562,共2页Chinese Journal of Convalescent Medicine

基　　金：全军保健专项课题(13BJ09)

摘　　要：目的探讨微小气候变化对老年2型糖尿病患者中性粒细胞和单核细胞膜CD11b/CD18表达的影响。方法对49例老年2型糖尿病疗养员所处的疗养室进行24 h/d空气净化以改善其居住的微小气候,每隔1个月应用流式细胞仪直接免疫荧光法检测CD11b/CD18,并与实验前对比。对照组住普通房间,不进行空气净化,分别于入院时和1个月后检测与实验组相同的指标。结果实验组治疗1个月后,患者的CD11b/CD18的表达较治疗前显著降低(P<0.01);对照组患者的各项指标均无显著性变化(P>0.05)。结论对老年2型糖尿病患者进行气候疗法,能显著改善其中性粒细胞和单核细胞膜CD11b/CD18表达,使病情得到改善。Objective To study the influence of mircroclimatotherapy on neutrophils and monocytes CD11b/CD18 expression of the elderly patients with type 2 diabetics. Methods The air of nursing rooms for 49 elderly convalescents with type 2 diabetics were purified for 24 hours one day so as to improve the microclimate and CD11b/CD18 was tested by means of flow cytometry with direct immunofluorescent method at the interval of one month,and the results were compared with those before the experiment.The control group were in the ordinary rooms without air purification,and the indexes indentical to the the experiment group were checked at the admission time and one month after the treatment. Results After one month of treatment,CD11b/CD18 expression of the experiment group remarkably decreased compared with that before the treatment（ P 〈0.01）.The indexes in the control group showed no remarkable changes（P 〉0.05）.Conclusion The mircroclimatotherapy can remarkably improve neutrophils and monocytes CD11b/CD18 expression of the elderly patients with type 2 diabetics so as to improve their state of illness.

关 键 词：气候疗法 老年人 糖尿病 CD11B/CD18 白细胞黏附分子 

分 类 号：R587.1[医药卫生—内分泌]