老年高血压患者认知功能与同型半胱氨酸的关系  

The relationship between cognitive impairment and homocysteine in elderly patients with hypertension

作　　者：刘薇[1] 马鑫[2] 刘楠[1] 李冰[1] 王静[1] 

机构地区：[1]解放军第四五一医院,陕西西安710054 [2]空军工程大学卫生处,陕西西安710054

出　　处：《西部医学》2015年第6期856-857,864,共3页Medical Journal of West China

基　　金：陕西省科学技术研究发展项目(2012SF2-02-4)

摘　　要：目的 探讨老年高血压患者认知功能障碍与同型半胱氨酸水平的关系.方法 选择2013年1月～2013年12月在解放军第四五一医院心血管内科住院的高血压患者310例,按照同型半胱氨酸在血浆中水平分为A组（Hcy＜10μmol/L）、B组（10 μmol/L≤Hcy＜20 μmol/L）和C组（10 μmol/L≤Hcy＜20 μmol/L）.采用简易精神状态量表（MMSE）及生活能力量表（ADL）对3组患者进行评分.结果 B、C两组患者的MMSE评分较A组均降低,且C组评分较B组显著降低;而B、C两组患者的ADL评分较A组均升高,且C组评分较B组显著升高.结论 老年性高血压合并高同型半胱氨酸血症患者更易发生认知功能损害,且认知功能损害程度与Hcy水平呈正相关.Objective To investigate the relationship between cognitive impairment and homocysteine in elderly pa- tients with hypertension. Methods 310 elderly hypertention patients were selected from the 451 Hospital of PLA be- tween January 2013 and December 2013. According to the plasmatic homocysteine levels the elderly hypertention patients were divided into three groups, A group（Hcy〈10 μmol/L, B group （10 μmol/L≤Hcy〈20 μmol/Lv）, C group （ Hcy≥ 20μmol/L）. The mini-mental state examination（MMSE） and the activities of daily living（ADL） were used to ealuate the cognitive function. Results The score of MMSE was decreased significantly in group B and C than in group A,and in group C than in group B. The score of ADL was increased significantly in group B and C than in group A,and in group C than in group B. Conclusion Elderly patients with hypertension and hyperhomocysteinaemia have higher risk for cogni- tive impairment, and higher Hcv level the more severe the cognition impaired.

关 键 词：同型半胱氨酸 高血压 认知功能障碍 

分 类 号：R544.1[医药卫生—心血管疾病] R743[医药卫生—内科学]