人工虫草多糖对阿霉素大鼠肾脏保护作用的实验观察  

Protect Effects of Cordyceps Polysaccharide on Adriamycin Induced Nephritic Syndrome in Rats

作　　者：胡剑卓[1] 邱细敏[2] 江建锋[1] 邱华丽[1] 

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005 [2]湖南师范大学医学院,湖南长沙410006

出　　处：《中医药导报》2015年第11期16-18,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省发改委科研项目(湘发改高技[2012]1493号);长沙市科技管理局科研项目(K1401010-31);湖南中医药管理局科研项目(2013146);湖南省科技厅科研专项项目(编号2014sk4040)

摘　　要：目的:观察人工虫草多糖对阿霉素模型大鼠肾脏的保护作用。方法:雄性SD大鼠尾静脉注射阿霉素,建立肾病综合征模型,分为模型组、激素组、人工虫草多糖组及正常对照组。连续药物灌胃21 d后,取肾组织观察病理学改变及Ⅰ、Ⅲ型胶原蛋白免疫组化。结果:与模型组比较,各药物组肾小球病理损伤减轻(P<0.01);人工虫草多糖组可减少Ⅰ、Ⅲ型胶原蛋白的沉积(P<0.01),且较强的松组减少更明显(P<0.05)。结论:人工虫草多糖能显著降低阿霉素大鼠的肾脏病理损伤,通过延缓肾小球硬化和肾间质纤维化的进展过程,对肾病综合征起到治疗作用。Objective： To observe the protect effects of cordyceps polysaccharide on the renal of rat model induced by adriamycin. Methods： Rat models of nephritic syndrome were established by tail intravenous of adriamycin; Model rats were ran- domly divided into model group, glucocorticoid group, cordyceps polysaccharide group and control group. Intragastric administra- tion was performed continually for 21 days. All rats were sacrificed to detect morphology of renal histology, Immunohistochemical localization of collagen I and collagen Ⅲ. Results： Compared with the model group,the drug group glomerular injury reduced in experiment group （P〈0.01）; Cordyceps polysaccharide is effective in inhibited the proliferation of mesangial matrix and mesangial cell and reduced the deposition of collagen I and collagen Ⅲ （P〈0.01）, which was more obvious than the glucocorticoid group （P〈0.05）. Conclusion： Cordyceps polysaccharide can relieve the lesion of kidney owing to the pathologic agents, fundamentally in- hibit thc ECM accumulation of ADR rats and slow thc processes of glomerulosclerosis and renal interstitial fibrosis.

关 键 词：人工虫草多糖 阿霉素 肾病综合征 胶原蛋白 

分 类 号：R285.5[医药卫生—中药学]