消化道肿瘤化疗患者营养状况与生活质量及化疗不良反应的相关性分析  

Correlation Analysis of Nutrition Status, Quality of Life and Chemotherapy Side-effects in Digestive Tract Cancer Patients Receiving Chemotherapy

作　　者：周婉[1] 许勤[1,2] 言克莉[3] 任驹茗 严凤[3] 

机构地区：[1]南京医科大学护理学院,江苏南京210029 [2]南京医科大学第一附属医院外科办公室,江苏南京210029 [3]南京医科大学第一附属医院肿瘤科,江苏南京210029

出　　处：《护理学报》2015年第9期1-4,共4页Journal of Nursing（China）

基　　金：国家卫生部临床重点专科建设项目(财社2010-305号);江苏省一级学科重点学科南京医科大学护理学开放基金资助项目(NYHL201402)

摘　　要：目的了解消化道肿瘤化疗患者营养状况,并探讨其营养状况与生活质量及化疗不良反应的相关性。方法采用方便抽样法,使用患者自评主观整体营养评估量表、癌症患者生活质量量表、通用不良反应事件评价标准及自行设计一般资料调查问卷,对某三级甲等医院肿瘤科150例消化道肿瘤化疗患者进行调查。结果 150例患者营养状况总分为(4.97±2.77)分,营养不良发生率为54.0%;生活质量中躯体功能、角色功能、情绪功能、认知功能、整体健康状况与营养状况总分呈负相关(P<0.05),疲乏、恶心呕吐、疼痛、失眠、食欲丧失、便秘、腹泻与营养状况总分呈正相关(P<0.05);化疗不良反应中白细胞减少、贫血、恶心、呕吐与营养状况总分呈正相关(P<0.05)。结论消化道肿瘤化疗患者营养状况总体较差,营养不良发生率较高,其营养状况与生活质量及化疗不良反应密切相关。因此,医护人员需采用营养筛查工具对消化道肿瘤化疗患者进行营养评估,早期给予营养干预,以提高其营养状况,减轻化疗不良反应,从而提高患者生活质量。Objective To explore the relationships of nutrition status, quality of life and chemotherapy side-effects for digestive tract cancer patients receiving chemotherapy. Methods With convenience sample method, 150 digestive tract cancer patients receiving chemotherapy were taken as subjects. Nutrition risk screening, quality of life and chemotherapy side-effect were respectively assessed by Patient Generated Subjective Global Assessment （PG-SGA）, European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30 （QLQ-C30） scales and The Common Terminology Criteria for Adverse Events （CTCAE） scales. Results The scores of nutrition were 4.97 ±2.77 and the prevalence of malnutrition was 54.0%. The scores of nutrition were negatively correlated with physical function, role function, emotional function, cognitive function and general health status, and positively correlated with fatigue, nausea and vomiting, pain, insomnia, appetite loss, constipation and diarrhea. The scores of nutrition were positively correlated with leukopenia, anemia, nausea and vomiting of chemotherapy side-effects. Conclusion The nutrition status of patients remains poor. A high prevalence of malnutrition in digestive tract cancer patients receiving chemotherapy is observed which is closely correlated with various functional dimensions of QOL and chemotherapy side-effect. Therefore, a better nutrition status of patients contributed by early nutritional support and diet care can result in the improved quality of life and reduced chemotherapy side-effects.

关 键 词：消化道肿瘤 营养状况 生活质量 化疗不良反应 

分 类 号：R473.57[医药卫生—护理学]