脱细胞气管支架再生上皮化的研究进展  

Research progress of re-epithelialization in decellularized trachea matrix

作　　者：陈燕玲[1] 何少茹[1] 

机构地区：[1]广东省医学科学院广东省人民医院新生儿科,广州510080

出　　处：《国际儿科学杂志》2015年第3期233-236,共4页International Journal of Pediatrics

基　　金：基金项目：国家“十二五”科技支撑计划项目（2011BAI11B22）

摘　　要：长段的气管缺损往往难以通过传统的外科手段治疗,需要进行气管移植.研究已证实组织工程技术在修复动物和人类气管缺损的能力,脱细胞气管支架因其良好的生物相容性等优点受到广泛的关注.组织工程气管的再生上皮化对于气管移植物有抵御感染,防止再狭窄等重要意义,是目前气管移植的主要难题之一.目前很多研究致力于组织工程气管的再生上皮化研究,但研究成果仍远未达到预期,需要进行更多的研究以确保组织工程气管应用的可行性.Long-segment tracheal defects are difficult to be managed by conventional surgical means,which often requires tracheal transplantation.Studies have confirmed that the capacity of tissue engineering techniques in restoration of extensive tracheal defects in animals and human.Decellularized tracheal matrix has attracted widespread attention for its advantages,such as excellent biocompatibility.Re-epithelialization of the tissue engineered trachea,which remains the major obstacle in tracheal transplantation,plays an important role in protecting the grafts from infection and restenosis.To date,some research focuses on the re-epithelialization of the tissue engineered trachea,but achievements are still far from desired,and further studies are needed to ensure the visibility of the application of tissue engineered trachea.

关 键 词：气管移植 组织工程 脱细胞气管支架 再生上皮化 

分 类 号：R726.5[医药卫生—儿科]