血培养和血清降钙素原检测对血流感染者早期诊治的临床价值  

Clinical value of procalcitonin detection and blood culture in early diagnosis of blood stream infection

作　　者：李明友[1] 林茂锐[1] 黄基伟[1] 刘桂治[1] 杨华文[1] 钟丽梅[1] 

机构地区：[1]广东省第二人民医院,广东广州510317

出　　处：《国际检验医学杂志》2015年第10期1381-1382,共2页International Journal of Laboratory Medicine

摘　　要：目的：探讨血培养和血清降钙素原（PC T ）联合检测对血流感染患者早期诊治的临床价值。方法对625例患者血标本用酶联荧光分析法（ELFA）测定血清PCT ，同时进行血培养，并对23例血培养阳性的重症患者血清PCT 进行多次检测和结果分析。结果血培养结果为阴性的患者（阴性组）PC T阳性率为41．01％（0．05～2．58μg／L ），血培养结果为阳性的患者（阳性组）PC T阳性率为80．77％（0．05～200．00μg／L ）。阳性组 PC T 阳性率高于阴性组，差异有统计学意义（χ^2＝65．12，P＜0．01）。假丝酵母菌、多种细菌、革兰阴性杆菌和革兰阳性球菌感染患者的PC T阳性率分别为100．00％、100．00％、92．11％和56．81％。对23例血培养阳性的重症患者进行了多次PC T检测，治疗过程中PC T水平逐渐降低者预后较好，PC T＞10μg／L且持续维持高水平者，其预后较差。结论同时进行血培养和PC T检测对血流感染患者的早期诊治有着重要的临床价值。Objective To explore the clinical value of procalcitonin （PCT ） and blood culture in the united diagnosis of early blood stream infection .Methods The blood specimens of 625 patients were collected ,the serum level of PCT was detected by EL‐FA ,and the blood culture was accessed at the same time .23 cases of blood culture positive samples were received continuous detec‐tion of PCT ,and the results were analyzed .Results Positive rate of PCT was 41 .01% （0 .05 -2 .58 μg/L）in patients with blood culture negative results （negative group） ,and that in patients with blood culture positive results （positive group） was 80 .77%（0 .05-200 .00 μg/L） .The positive rate of PCT in positive group was significantly higher than negative group （χ^2 =65 .12 ,P〈0 .01） .Positive rates of PCT in patients with infection of Candida tropicalis ,kinds of bacteria ,Gram‐negative bacilli and Gram‐posi‐tive cocci were 100 .00% ,100 .00% ,92 .11% and 56 .81% ,respectively .Continuous detection of PCT in 23 patients with blood cul‐ture positive results showed that patients with gradually decreased PCT level suggested a good prognosis ,and patients whose PCT levels were higher than 10 μg/L and were maintained at high levels had poor prognosis .Conclusion Simultaneously blood culture and PCT detection was important to the early diagnosis and treatment of blood stream infection .

关 键 词：血培养 血清降钙素原 血流感染 

分 类 号：R446.5[医药卫生—诊断学]