CK-MB及cTnI对手足口病患儿心肌损伤的诊断价值研究  

Clinical significance of CK-MB and cTnI for the diagnosis of myocardial injury in children with hand-foot-mouth disease

作　　者：蔡德建[1] 田玫玲[1] 吴殿水[1] 卢庆乐[1] 

机构地区：[1]山东大学附属省立医院检验科,山东济南250022

出　　处：《国际检验医学杂志》2015年第10期1383-1384,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)对手足口病(HFMD)患儿心肌损伤的诊断价值。方法选择2012年7月至2013年6月住院治疗的HFMD患儿80例(HFMD组),同期体检健康儿童50例(对照组)。比较两组血清CK-MB、cTnI水平。结果 HFMD组治疗前CK-MB、cTnI水平分别为(38.10±19.50)U/L、(0.08±0.02)μg/L,均高于对照组(P<0.05)。HFMD患儿治疗前CK-MB、cTnI阳性率分别为56.3%、33.8%,阳性率比较差异有统计学意义(P<0.05)。经治疗后,HFMD患儿CK-MB、cTnI水平均明显下降(P<0.05)。结论联合检测血清CK-MB、cTnI对HFMD合并心肌损伤的早期诊断具有重要临床意义。Objective To explore the diagnostic value of serum creatine kinase isoenzyme MB （CM‐MB） and cardiac troponin I （cTnI） for myocardial injury in children with hand‐foot‐mouth disease （HFMD） .Methods A total of 80 children with HFMD （HFMD group） and 50 healthy children （control group） were enrolled from July 2012 to June 2013 .Serum levels of CK‐MB and cTnI were compared between the two groups .Results Serum levels of CK‐MB and cTnI were （38 .10 ± 19 .50）U/L and （0 .08 ± 0 .02）μg/L in HFMD group ,which were higher than control group （P〈0 .05） .In HFMD group ,the positive rate of CK‐MB was 56 .3% ,higher than the 33 .8% of cTnI （P〈 0 .05） .After therapy ,serum levels of CK‐MB and cTnI were both significantly de‐creased （P〈0 .05） .Conclusion Combined detection of serum CK‐MB and cTnI might be with important significance for the early diagnosis of myocardial injury in children with HFMD .

关 键 词：手足口病 肌酸激酶同工酶 肌钙蛋白I 心肌损伤 

分 类 号：R725.1[医药卫生—儿科] R446.1[医药卫生—临床医学]