颈动脉粥样硬化与冠心病的相关性研究及危险因素分析  

Correlation of carotid atherosclerosis with coronary heart disease and the risk factors

作　　者：叶胜[1] 杨凌飞[1] 周家砚[1] 贺常萍[1] 汤圣兴[2] 

机构地区：[1]皖南医学院第二附属医院心内科,安徽芜湖241000 [2]皖南医学院附属弋矶山医院心内科,安徽芜湖241001

出　　处：《皖南医学院学报》2015年第3期232-235,共4页Journal of Wannan Medical College

基　　金：皖南医学院重点科研基金项目(WK2014ZF17)

摘　　要：目的:探讨颈动脉粥样硬化与冠心病的相关性,分析与其相关的危险因素,为冠心病的早期诊断和治疗提供依据。方法:选取我院拟诊冠心病患者进行冠状动脉造影检查(CAG),依据冠脉造影检查结果将拟诊冠心病患者分为冠心病组及对照组,对其进行颈动脉超声检查患者颈动脉内-中膜厚度(IMT)及斑块积分(Crouse),同时检测患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及血清同型半胱氨酸(HCY)水平,所有结果均采用SPSS 16.0软件包进行统计学分析。结果:本次研究共收集了183例拟诊冠心病患者,其中冠心病组82例,对照组101例,经统计分析:冠心病组患者的IMT、Crouse积分均高于对照组(P<0.05);两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白固醇(LDL-C)水平相比无统计学意义(P>0.05);冠心病组患者的高密度脂蛋白胆固醇(HDL-C)水平低于对照组,有统计学意义(P<0.05);冠心病组的HCY水平高于对照组,差异有统计学意义(P<0.01)。结论:颈动脉内-中膜厚度(IMT)及斑块形成与冠心病有着明显的相关性,HDL-C的降低和HCY的升高是动脉粥样硬化性疾病的危险因素。Objective： To investigate the correlation of carotid atherosclerosis with coronary heart disease（ CHD） and the risk factors for evidence for early diagnosis and treatment of this conditions. Methods： Coronary arteriongraphy（ CAG） was performed in suspected CHD patients,who were divided into CHD group and control group in compliance with CAG findings. Then two groups of patients were subjected to ultrasonic examination to measure the intimamedia thickness（ IMT） and estimate the plaque index by Crouse method,and were determined regarding levels of serum TG,TC,HDL-C,LDL-C and HCY. All results were computed with software SPSS,version 16. 0. Results： A total of 183 suspected CHD cases were included,in which 82 were CHD,and101 were controls. Statistics showed that IMT and Crouse scoring were higher in CHD group than those of the control group（ P〈0. 05）. The two groups were not significant concerning the levels of TC,TG and LDL-C（ P 〉0. 05）,yet CHD patients had lower HDL-C level and higher HCY than the controls（ P〈0. 05,P 〈0. 01,respectively）. Conclusion： IMT and plaque formation are significantly associated with CHD occurrence,and reduced HDL-C level yet elevated HCY are risk factors for atherosclerotic conditions.

关 键 词：颈动脉粥样硬化 冠心病 同型半胱氨酸 高密度脂蛋白胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]