坎地沙坦联合曲美他嗪治疗原发性高血压左室肥厚的临床观察  

Clinical observation of Candesartan combined with Trimetazidine on treating ventriculus sinister hypertrophy of essential hypertension

作　　者：王春梅[1] 文军[1] 丁润会 刘叶[1] 嵇诚[1] 郭景华[1] 袁志勇[1] 

机构地区：[1]秦皇岛市海港医院,河北秦皇岛066000

出　　处：《药学研究》2015年第5期304-305,共2页Journal of Pharmaceutical Research

摘　　要：目的观察坎地沙坦联合曲美他嗪治疗原发性高血压左室肥厚的疗效。方法原发性高血压患者115例,随机分为两组,A组采用坎地沙坦口服,B组采用坎地沙坦联合口服曲美他嗪,比较两组降压效果、超声心动图指标的改变。结果两组患者血压均较治疗前明显下降(P<0.05),但两组间降压效果比较无统计学差异(P>0.05);两组LVEDd、LVPWT、IVST、LVMI、LVEF及E/A均显著改善,且B组均优于A组(P<0.05)。结论采用坎地沙坦联合曲美他嗪较单纯采用坎地沙坦治疗可更明显逆转原发性高血压左室肥厚、改善心功能。Objective To observe the curative effect of Candesartan combined with Trimetazidine on treating ventriculus sinister hypertrophy of essential hypertension. Methods 115 cases of essential hypertension patients were divided into two groups randomly. A group was treated by Candesartan orally and B group was treated by Candesartan combined with Trimetazidine. The antihypertensive effect and changes of echocardiogram index of two groups were compared. Results Compared with pretherapy,the blood pressures of patients in two groups were obviously reduced（ P 〈 0. 05）,but the antihypertensive effects had no statistics difference（ P 〉 0. 05）. LVEDd,LVPWT,IVST,LVMI,LVEF and E / A in two groups were obviously improved and B group was all better than A group（ P 〈 0. 05）. Conclusion Compared with treating only with Candesartan,Candesartan combined with Trimetazidine can obviously reverse the ventriculus sinister hypertrophy of essential hypertension and improve heart function.

关 键 词：坎地沙坦 曲美他嗪 高血压 左室肥厚 

分 类 号：R969.4[医药卫生—药理学]