异丙醇铝参与下的异植物醇合成工艺研究  

Improved synthsis of isophytol catalyzed by aluminium isopropoxide

作　　者：谢建勇[1] 马欢[1] 刘浩[1] 李勤耕[1] 

机构地区：[1]重庆医科大学药学院,重庆400016

出　　处：《化学研究与应用》2015年第5期629-634,共6页Chemical Research and Application

摘　　要：以丙酮为起始原料,经过格氏反应、Carroll重排、氢化反应得到异植物醇,总收率69.4%。该工艺提高收率的关键步骤Carroll重排反应选用异丙醇铝为催化剂,并对反应机理进行了初步探讨。目标产物和关键中间体经MS谱,1H-NMR谱等确证了结构。改进后的合成工艺路线生产设备简单,条件温和,收率高,适合大规模化生产。The target compound was synthesized through Grignard reaction,Carroll rearrangement and hydrogenation reaction from acetone with an overall yield of 69. 4%. Carroll rearrangement,the key step to improve the yield,was catalyzed by aluminum iso-propoxide,and the corresponding reaction mechanism was investigated preliminarily. The target compound and key intermediates were confirmed by MS and 1 H-NMR. The improved synthesis was benefited from simple equipment,mild conditions,high yield and could be readily scale-up to mass production.

关 键 词：维生素E 异植物醇 格氏反应 Carroll重排 合成 

分 类 号：O629.4[理学—有机化学]