聚乙二醇-600中CuSO_4/葡萄糖催化下二苯基硫脲的合成  

Synthesis of diphenylthioureas catalyzed by CuSO_4/ glucose in PEG-600

作　　者：侯荣杰 王方建[1] 吴浩浩[1] 张泽[1] 

机构地区：[1]安徽工程大学生物与化学工程学院,安徽芜湖241000

出　　处：《化学研究与应用》2015年第5期679-683,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(21242013)资助;国家级大学生创新创业训练计划项目(201310363072)资助

摘　　要：以聚乙二醇-600为反应介质,在Cu SO4/葡萄糖催化作用下,取代苯胺与硫脲有效缩合生成了一系列相应的苯基硫脲。反应产物经水洗、过滤、乙醇/水中重结晶即可获得。该方法不使用有毒有机溶剂,原料及催化剂价廉,后处理简单便捷,因此是合成该类化合物高效绿色的新方法。所有产物经熔点、红外、核磁共振氢谱进行了表征。A series of diphenylthioureas were efficiently synthesized through condensation of anilines with thiourea catalyzed by Cu-SO4/glucose in PEG-600. The products were obtained just by washing with water, filtration and recrystallization from EtOH/H2 O. The present method exhibited the following advantages：free use of toxic organic solvent,cheap starting materials and catalyst, and simple work-up procedure. These merits made it an efficient and green alternative to synthesis of diphenylthioureas. All the products were characterized with m. p. ,IR and 1 H-NMR analysis.

关 键 词：二苯基硫脲 硫酸铜/葡萄糖 聚乙二醇-600 绿色有机合成 PEG-600 

分 类 号：O626[理学—有机化学]