2-取代硫醚-5-脱氢松香基-1,3,4-恶二唑/噻二唑类化合物的合成及生物活性  

Synthesis and biological activities of 2-alkylthio-5-dehydroabietyl-1,3,4-oxadiazole /1,3,4-thiadiazole derivatives

作　　者：杨小洪[1,2] 曹宇[1,2] 史伯安[1,2] 雷福厚 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000 [2]广西林产化学与工程重点实验室,广西南宁530006

出　　处：《化学研究与应用》2015年第5期717-721,共5页Chemical Research and Application

基　　金：广西林产化学与工程自治区重点实验室项目(GXFC14-07)资助;国家民委项目(12HBZ007)资助

摘　　要：以脱氢松香酸为原料,经酯化、肼解、关环和亲核取代反应得到了2-取代硫醚-5-脱氢松香基-1,3,4-恶二唑和2-取代硫醚-5-脱氢松香基-1,3,4-噻二唑类化合物。通过IR、MS、1H NMR和元素分析对产物进行了表征。初步生物活性检测结果表明,所有目标化合物都表现出一定的除草活性。2-Alkylthio-5-dehydroabietyl-1,3,4-oxadiazole and 2-alkylthio-5-dehydroabietyl-1,3,4-thiadiazole were obtained from dehydroabietic acid through esterification, hydrazinolysis reaction, cyclization and nucleophilic substitution. Their structures were characterized by means of IR,1 H NMR,MS and elemental analysis. Preliminary bioassay indicated that all the compounds displayed herbicidal activity to some extent.

关 键 词：脱氢松香酸 1  3  4-噻二唑 1  3  4-恶二唑 合成 生物活性 

分 类 号：O621[理学—有机化学]