徐州地区39997例女性生殖道人乳头瘤病毒检测结果分析  

Analysis of detection of human papilloma virus in 39997 cases in Xuzhou

作　　者：任玲[1] 石启明[1] 

机构地区：[1]江苏省徐州市妇幼保健院宫颈疾病诊治中心,江苏徐州221009

出　　处：《现代预防医学》2015年第11期1996-1998,2002,共4页Modern Preventive Medicine

摘　　要：目的了解徐州地区妇女生殖道人乳头瘤病毒（HPV）感染情况。方法采用凯普医用核酸分子杂交技术及其配套试剂对2009年2月-2012年5月于我院体检、就诊的39 997例女性行生殖道人乳头瘤病毒分型检测,分析HPV感染及亚型分布情况。结果 （1）39 997例女性中HPV阳性8 369例,阳性率20.92%;（2）其中单一感染6 305例,占阳性病例的75.34%,多重感染2 064例,占阳性病例的24.66%;单一感染与多重感染比较差异有统计学意义（χ2=5 723.03,P〈0.0001）;（3）感染的高峰年龄为20岁以下组,感染率30.21%。随年龄增长,HPV感染率逐渐下降,51～60岁组出现HPV感染的第二个高峰,感染率为21.82%;（4）HPV高危亚型感染7 079例,低危亚型感染2 116例,两者比较差异有统计学意义,（χ2=2931.16,P〈0.0001）;（5）随年龄的增加HPV高危亚型的感染率逐渐升高,低危亚型的感染率逐渐降低,各年龄组间单一高危型感染率差异具统计学意义,（χ2=55.45,P〈0.0001）。（6）21种HPV亚型均被检出,感染率排前六位的亚型为16、58、52、53、CP8304、11。其中HPV16感染率与其他各型相比差异有统计学意义,P〈0.0001。HPV58感染率与其他各型相比差异有统计学意义（P〈0.01）。结论徐州地区女性HPV感染率较高,以单一、高危型感染为主,HPV16、58、52、53是主要的感染亚型。Objective To study the situation of human papilloma virus （HPV） infection in the female lower genital tract in Xuzhou City. Methods We took the cape of a nucleic acid molecule hybridization technique and its supporting reagent, to analyze the distribution of HPV infection and subtypes from 39997 cases of female genital HPV classification test in the maternal and child health hospital of Xuzhou from February 2009 to May 2009. Results （1） Among the 39997 patients, 8369 cases were infected with HPV, and the overall HPV prevalence was 20.92%. （2） 6305 cases （75.34%） were single HPV type infection. 2064 cases （24.66%） were multiple infection, and there was a significant difference between the single HPV type infection and multiple infection （~=5723.03, P〈0.O001）. （3） The highest HPV prevalence was found in women under twenty, and the infection rate was 30.21%. Along with the growth of age, HPV infection rate gradually decreased. And the second highest infection rate was 21.82 among people aging from 51 to 60. （4） 7079 cases were infected with the high risk subtype of HPV, the low risk HPV had 2116 cases. There was a significant differences between the two subtypes （x2= 2931.16, P〈0.05）. （5） Along with the growth of age, the high risk subtype of HPV infection rate was gradually rising, and the low risk HPV gradually decreased. The rate of high risk single HPV in different age groups had significant differences （x2=55.45, P〈0.0001）. （6） 21 kinds of HPV subtypes were detected and the 6 most common subtypes were （in descending order）： HPVI6, HPV58, HPV52, HPV53, CP8304, HPV11. The infection of HPV16 and HPV58 had a significant difference compared with each other （P〈0.01）. Conclusion The research found that the high HPV infection among women in Xuzhou, especially the single and the high risk subtype of HPV type infection. HPV16, HPV58, HPV52, HPV53, CP8304 are the most common subtypes.

关 键 词：人乳头瘤病毒 徐州地区 基因亚型 

分 类 号：R17[医药卫生—妇幼卫生保健]