乙肝HBeAg、前S1-抗原与HBV-DNA相关性研究  

Correlation between HBE Ag, Pre-S1 antigen and HBV-DNA

作　　者：邵咏[1] 吕惠娟 邢志广[1] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002 [2]新乡市卫校,河南新乡453000

出　　处：《现代预防医学》2015年第11期2069-2071,共3页Modern Preventive Medicine

摘　　要：目的探讨乙肝HBe Ag、前S1-抗原和HBV-DNA的相关性,为临床诊疗提供实验室依据。方法乙肝HBe Ag和前S1-抗原检测采用ELISA法,HBVDNA载量采用PCR-荧光探针法。结果 （1）前S1-抗原阳性率HBe Ag（＋）组91.25%（73/80）显著高于HBe Ag（-）组25.48%（40/157）（χ2=37.552,P〈0.005）;HBVDNA阳性率HBe Ag（＋）组88.75%（71/80）亦显著高于HBe Ag（-）组29.30%（46/157）（χ2=30.508,P〈0.05）。（2）HBe Ag阳性率HBV-DNA高水平复制组（即〉107拷贝/ml）82.22%（37/42）显著高于低水平复制组（即103～105拷贝/ml）45.0%（9/20）（χ2=10.78,P〈0.05）;前S1-抗原阳性率HBV-DNA高水平复制（即〉107拷贝/ml）组96.15%（42/45）亦显著高于低水平复制（即103～105拷贝/ml）组45.0%（9/45）（χ2=30.508,P〈0.005）。结论乙肝HBe Ag、前S1-抗原与HBV-DNA检测,一致性较好,两者均可作为乙肝病毒复制和传染的实验室指标。Objective To explore the correlation between HBE Ag, Pre-S1 antigen, HBV-DNA, and provide basis for clinical diagnosis and treatment. Methods The detection of HBeAg and pre-S1 antigen were carried out by the ELISA method, and HBVDNA load was detected by the PCR- fluorescent probe method. Results Pre-S1 antigen positive rate of HBE Ag （＋） group was significantly higher than that of the negative group （P〈0.005）; HBV DNA positive rate of HBE Ag （＋） group was significantly higher than that of HBE Ag （-） group （P〈0.05）. The HBE Ag positive of HBV - high levels of DNA replication was significantly higher than that of low copy group （P〈O.05）. Pre-S 1 antigen positive rate of HBV - high levels of DNA replication were significantly higher than that of the low level copy group. Conclusion The positive rates of HBE Ag, pre S1- antigen and HBV-DNA have high consistency, and all can be used as laboratory indicators of the HBV replication and infection.

关 键 词：HBE Ag 前S1-抗原 HBV-DNA载量 

分 类 号：R186[医药卫生—流行病学]