宫颈癌的生物标志物分析及其临床应用前景  

Analysis of the biomarkers and its prospect of clinical application in cervical cancer

作　　者：常迎香[1] 陈红青[1] 南凤艳 

机构地区：[1]衡水市第四人民医院妇产科,河北衡水053000

出　　处：《现代预防医学》2015年第11期2107-2109,共3页Modern Preventive Medicine

摘　　要：宫颈癌是一种常见的妇科恶性肿瘤,其发病率位于女性肿瘤第二位,仅次于乳腺癌。目前宫颈癌呈年轻化的趋势,鉴于宫颈癌的早期治愈率很高,早发现早治疗是应对宫颈癌的最有效方式,但目前的宫颈涂片检查敏感度低,重复性差等特点是制约早期诊断的一个重要瓶颈。人乳头瘤病毒的感染是宫颈癌发生的明确病因,因此,寻找人乳头瘤病毒调节的生物标志物对于疾病的早期发现、预防、治疗以及预后都有着十分重要的意义。在此,本文对宫颈癌的一些特异性分子标志物进行了总结,这些标志物的顺利开发在临床检测和治疗上有着非常重要的意义。Cervical cancer is a common gynecologic tumor among women, and its incidence ranks second behind the breast cancer. Currently more and more young women are suffering from cervical cancer. This sort of cancer could have a high cure rate in the early stage and therefore, the optimal strategy for the treatment is to treat the disease as early as possible. However, the current Papanicolaou test （Pap test） is limited to its low sensitivity and poor repeatability at the period of the early diagnosis. Now we know that the infection of human papillomavirus （HPV） is its etiology, and it is critical to find the reliable HPV-mediated biomarkers for diagnosis, prevention, treatment and prognosis of this disease. In this paper we summarize some specific molecular markers of cervical cancer, and the markers has the significance for the successful development of these biomarkers in clinical application.

关 键 词：宫颈癌 生物标志物 人乳头瘤病毒 预后 诊断 

分 类 号：R17[医药卫生—妇幼卫生保健]