建立输血不良反应监测体系连续对发热性非溶血性输血反应的监测与分析  

Analysis and surveillance on a hemovigilance system for monitoring transfusion reactions and febrile non-hemolytic transfusion reactions

作　　者：周吉成[1] 沈德才[1] 谭彬宾[1] 韦喜敢[1] 周建月[1] 石雄英 

机构地区：[1]广西医科大学第一附属医院输血科,广西南宁530021

出　　处：《中国输血杂志》2015年第4期405-407,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探讨发热性非溶血性输血反应(FNHTR)的发生率及发病的相关因素。方法建立输血不良反应的监测体系,连续监测2006年1月-2014年9月本院门诊或/和住院患者FNHTR的发病情况,对确诊的280例FNHTR的临床资料进行分析。结果 1)输注血小板、红细胞、血浆及冷沉淀患者FNHTR的发生率分别为0.8‰(33/43 684)、0.42‰(156/374 343)、0.17‰(88/519 460)和0.08‰(3/38 361);2)输注悬浮红细胞与少白红细胞的FNHTR的发生率分别为0.50‰(119/240 232)vs 0.28‰(37/134 111)(P<0.05);3)男性和女性FNHTR患者有输血史的比例分别为72.4%(121/167)vs 71.7%(81/113)(P>0.05)。结论引起FNHTR的血液成分主要是血小板;输注少白细胞红细胞可明显降低FNHTR的发生率;输血史是FNHTR的高危因素。Objective To investigate the incidence of febrile non-hemolytic transfusion reactions( FNHTR) and related factorsof its pathogenesis. Methods A hemovigilance system of transfusion reaction was conducted to monitor continuously the FNHTR from January 2006 to September 2014 among the outpatients and / or inpatients of the First Affiliated Hospital of Guangxi Medical University,followed by an analysis on 280 clinical datas of FNHTR which were diagnosed during this period. Results 1) The incidence of FNHTR caused by platelets,red blood cells,plasma and cryoprecipitate were 0. 8‰(33 /43 684),0. 42‰( 156 /374 343),0. 17‰( 88 /519 460) and 0. 08‰( 3 /38 361),respectively. 2) The incidence of FNHTR caused by red cells suspension and leukocyte reduced red cells were 0. 50‰( 119 /240 232) vs 0. 28‰( 37 /134111)( P<0. 05). 3) The rates of male FNHTR patients and female FNHTR patients with a history of transfusion were72. 4%(121 /167) vs 71. 7%(81 /113)( P>0. 05). Conclusion As blood components,platelets mainly cause FNHTR.The incidence of FNHTR can significantly be reduced by transfusing leukocyte reduced red cells. Transfusion history may be a risk factor of FNHTR.

关 键 词：发热性非溶血性输血反应 发生率 血液成分 血小板 少白红细胞 输血史 

分 类 号：R457.13[医药卫生—治疗学]