四川地区血站分离血浆HIV/HBV/HCV残余风险研究  

Evaluation of residual risk of HIV,HBV and HCV in recovered plasma in Sichuan Province

作　　者：韩婷婷[1] 刘鱼[2] 李长清[2] 张燕 王娅[2] 柯玲[2] 吴秉婷[2] 刘桂[2] 刘忠[2] 

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]中国医学科学院北京协和医学院输血研究所 [3]成都蓉生药业有限责任公司

出　　处：《中国输血杂志》2015年第4期420-423,共4页Chinese Journal of Blood Transfusion

摘　　要：目的评估四川地区血站分离血浆中HIV、HBV、HCV的残余风险。方法收集2013年1-12月四川9家血站HBs Ag、抗-HCV、抗-HIV筛查阳性样本,对筛查HBs Ag阳性标本采用中和试验确证,对筛查抗-HCV及抗-HIV阳性标本采用免疫印迹法确证。采用改良的发病率-窗口期模型计算HBV,HCV,HIV残余风险。结果四川地区血站分离血浆中HBV,HCV和HIV的残余风险分别为1/1 355,1/35 587和1/92 593。结论血站分离血浆仍存在一定残余风险,增加核酸检测等新型检测技术可进一步降低其残余风险。Objective To evaluate the residual risks of HIV,HBV and HCV in recovered plasma in blood centers of China. Methods Samples which were screened reactive for HBs Ag,anti-HCV and anti-HIV were collected from nine blood centers in Sichuan,and then were subjected to confirmatory testing and neutralization assay for HBs Ag,RIBA for HCV and Wester-blot for HIV. The residual risk of HBV,HCV and HIV were calculated by a modified incidence-window model. Results The residual risks of HBV,HCV and HIV in blood centers of Sichuan province were 1 /1 355,1 /35 587,and1 /92 593,respectively. Conclusion The residual risks of recovered plasma still exist and more measures should be taken to reduce the risk of transfusion-transmitted infection diseases,such as the application of nucleic acid testing.

关 键 词：HBV HCV HIV 残余风险 分离血浆 

分 类 号：R446[医药卫生—诊断学] R373.21[医药卫生—临床医学]