伏格列波糖分散片联合五参口服液对气阴两虚型糖耐量低减患者干预作用的临床研究  

Clinical Study on Impaired Gluocse Tolerance of Qi and Yin Deficieney Syndrome Treated with Voglibose Dispersible Tablet Combined Wushen Oral Liquid(五参口服液)

作　　者：肖凤英[1] 崔金涛[1] 贺劲[1] 李敏[1] 张军[1] 余淑菁[1] 

机构地区：[1]湖北省武汉市中医医院,武汉430014

出　　处：《中国中医药科技》2015年第3期252-254,265,共4页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察伏格列波糖分散片(家能)联合五参口服液干预治疗糖耐量低减(IGT)的转归、症状变化及其不良反应,以探求糖尿病(DM)二级预防的最佳方式方法。方法:选择IGT 60例随机分为家能组、家能加五参口服液组(五参联合组)及安慰剂组,3组均在糖尿病饮食、运动疗法的基础上,连续服药治疗8周。治疗前后所有患者均检测空腹血糖(FPG)、口服75 g OGTT后半小时、2小时的血糖(2 h PG)、糖化血红蛋白和空腹胰岛素分泌水平(FINS)及糖负荷后半小时胰岛素水平,并计算3组治疗前后胰岛素敏感性指数(ISI)、早期胰岛素分泌指数(△Ins30/△Glu30)、胰岛素抵抗指数(HOMA-IR)、胰岛B细胞功能指数(HOMA-P),检测其服药后血常规、肝功能、血脂、肾功能、体质量指数(BMI)及其血压变化,并记录用药期间不良反应情况。结果:治疗后,家能组及家能加五参组2 h PG较治疗前明显下降(P<0.05),ISI、HOMA-IR、HOMA-、△Ins30/△Glu30明显改善(P<0.05),与安慰剂组比较改善明显(P<0.05)。体质量指数家能加五参组较家能组及安慰剂组下降明显(P<0.05)。家能组、家能加五参组两组糖耐量转为正常比率分别为97.6%、98%。血常规、血脂、肝功能、肾功能及血压各组治疗前后无明显变化(P>0.05)。家能加五参组症状较家能组及安慰剂组改善明显,不良反应腹胀、腹泻、腹痛、便秘及低血糖、皮疹发生率明显低于家能组及安慰组(P<0.05)。结论:伏格列波糖分散片能明显增加IGT向正常糖耐量(NGT)的转化率,明显降低IGT餐后血糖、增加早期胰岛素分泌,改善胰岛素抵抗及胰岛B细胞功能,联合五参口服液治疗可明显改善IGT症状,增强上述作用,减少不良反应的发生。Objective： To observe the treatment changes of Voglibose Dispersible Tablet （Jia＇ neng） ＋ Wushen Oral Liquid on impaired glucose tolerance （ IGT）, and to explore the best way of two levels of prevention of diabetes mellitus （DM）. Methods：60 IGT patients were randomly divided into Jia＇ neng group, Jia＇ neng ＋ Wushen Oral Liquid group, and placebo group, three groups were treated for 8 weeks on the basis of diabetes di- et, exercise therapy. Before and after treatment, all patients were tested fasting blood glucose （FPG）, 2h plas- ma glucose （2 h PG）after 75g OGTF, glycosylated hemoglobin and fasting insulin level （FINS） and half an hour insulin level after 75g OGTI. And insulin sensitivity index （ISI）, insulin secretion index （ A Ins30/ A Glu30）, insulin resistance index （HOMA- IR）, islet B cell function index（ HOMA -P）. The blood routine, liver function, serum lipid, renal function, body mass index （BMI） and the changes of blood pressure were test- ed after treatment, adverse reactions were recorded during the course of medication. Results： Compared with be- fore treatment, 2 h PG was significantly lower after treatment in Jia＇ neng group, and Jia＇ neng ＋ Wushen Oral Liquid group （ P 〈 0.05 ）. ISI, HOMA - IR, HOMA - 13, A Ins30/A Glu30 were improved significantly （ P 〈 0. 05 ） compared with the placebo group （ P 〈 0.05 ） ; body mass index decreased significantly in Jia＇ neng ＋ Wush- en Oral Liquid group, compared with the Jia＇ neng group and placebo group （ P 〈 0.05 ）. Glucose tolerance to normal ratios were 97.6%, 98% in Jia＇ neng group,and Jia＇ neng ＋ Wushen Oral Liquid group. The blood rou- tine, blood lipid changes, liver function, renal function and blood pressure in each group were no change （ P 〉 0.05 ）. Syndroms were improved significantly in Jia＇ neng ＋ Wushen Oral Liquid group, adverse reactions, such as abdominal distensions of diarrhea, abdominal pain,rash, constipation and hypoglycemia inci

关 键 词：糖耐量低减 气阴两虚 伏格列波糖分散片 五参口服液 

分 类 号：R587.1[医药卫生—内分泌]