病炎清颗粒对流感病毒感染小鼠治疗作用的实验研究  

Protection of Bingyanqing Granule(病炎清颗粒) on Influenza Virus Infection in Mice

作　　者：祝庆华[1] 曲敬来[1] 高雪[1] 余燕[1] 

机构地区：[1]深圳市中医院,深圳518033

出　　处：《中国中医药科技》2015年第3期268-269,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：广东省中医药局科研立项课题(20121049)

摘　　要：目的:观察病炎清颗粒对流感病毒FM1感染小鼠的治疗作用。方法:用流感病毒FM1感染小鼠,将实验小鼠随机分为正常组、模型组、西药组、中药组;分组给药5天,观察小鼠肺指数、抑制率及感染后小鼠肺组织IFN-γ含量及血清Ig M含量的变化。结果:病炎清颗粒组能明显降低流感病毒感染小鼠的肺指数及抑制率,提高病毒感染小鼠肺组织IFN-γ表达及血清Ig M含量。结论:病炎清颗粒对流感病毒FM1感染小鼠具有治疗作用,增强免疫功能是其部分作用机制。Objective：To study the effects of Bingyanqing Granule on influenza virus FM1 infection in mice. Methods：The expermental mice were randomly divided into normal, model, western medicine and Chinese medi- cine groups, each group was given the corresponding .medicine for 5 days. Observing the pulmonary index of mice, the inhibition rate and the changes of IFN - y and serum IgM contents. Results： Bingyanqing Granule could obviously reduce the pulmonary index of influenza virus infection in mice and inhibition rate, increase lung tissue IFN - y expression and serum IgM content. Conclusion ： Bingyanqing Granule has a therapeutic effect on influen- za virus FM1 infection in mice ,enhencing immumologic function is the part of mechanirsm.

关 键 词：流感 流感病毒FM1 病炎清颗粒 肺指数 IFN-Γ IGM 小鼠 

分 类 号：R285.5[医药卫生—中药学]