水溶性高分子基H_2S供体的合成及其光释放H_2S的研究  

Synthesis and Investigation of Water-soluble and Photocontrollable Polymeric Hydrogen Sulfide

作　　者：王林[1] 李钟玉[1] 兰云军[1] 

机构地区：[1]浙江省碳材料温州大学化学与材料工程学院皮革技术研究重点实验室,浙江温州325027

出　　处：《化工技术与开发》2015年第5期29-32,共4页Technology & Development of Chemical Industry

摘　　要：硫化氢(H2S)是继NO和CO后新发现的一种信号分子,对细胞具有保护作用。近些年来,H2S在生物学和药理学领域的研究取得了一些重大进展,但仍然有大量的基本问题有待解决。本研究结合高分子药物传输理念和光释放药物的方法合理地设计了一种包含偕取二硫醇型基本结构单元的高分子H2S释放源。Hydrogen sulfide （H2S） was a newly recognized signaling molecule with very potent cytoprotective actions. Although the fields of H2S physiology and pharmacology had rapidly growing in recent years, a number of fundamental issues still need to be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Herein, we rationally designed and synthesized a new ideal H2S donor using the concept of polymeric drug delivery and stimuli-responsiveness.

关 键 词：硫化氢 信号分子 光释放 

分 类 号：TQ251.12[化学工程—有机化工]