Ⅱ型糖尿病患者血糖对肝功能和血脂的影响及其意义  

Effect of Blood Glucose Level on Liver Function and Blood Lipid in TypeⅡ Diabetes Mellitus

作　　者：罗苗[1] 李军民[2] 李梦颖[1] 谈昀[2] 王俊红[3] 权晓娟[3] 张磊[1] 刘寒强[1] 王枫[1] 

机构地区：[1]第四军医大学营养与食品卫生学教研室,陕西西安710032 [2]武警陕西总队医院检验科,陕西西安710054 [3]西安交通大学第二附属医院内分泌科,陕西西安710004

出　　处：《现代生物医学进展》2015年第17期3268-3272,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81201928)

摘　　要：目的:探讨II型糖尿病患者血糖浓度对患者肝功能及血脂指标的影响及其意义。方法:选取某三级甲等医院内分泌科已确诊为II型糖尿病患者408例,根据空腹血糖浓度(FPG)分为三组:(A组,FPG<8.0 mmol/L;B组,8.0≤FPG<11.0 mmol/L;C组,FPG≥11 mmol/L),检测三组患者的肝功能指标及血脂指标,进而对其肝功能损害及血脂的异常情况进行分析,其数据结果应用统计学软件SPSS 17.0处理。结果:与A组及B组相比较,C组患者肝功能损伤更为严重,表现为:肝酶显著升高(P<0.05);胆红素显著升高(P<0.05);球蛋白显著升高(P<0.05);总胆固醇、甘油三酯水平异常(P<0.05)。其结果均有统计学意义。结论:II型糖尿病患者随着其血糖浓度升高可造成肝功能损伤及血脂异常,血糖监测及控制对糖尿病患者的身体健康状况具有重要意义。Objective： To analysis the effect of blood glucose level on liver function and blood lipid in type Ⅱ diabetes mellitus patients. Methods： 408 patients newly diagnosed with type Ⅱ diabetes mellitus aged from 14 to 89 years from November 2013 to May2014 were collected. All patients were divided into three groups according to the concentration of fasting plasma glucose（FPG）（group A, the FPG8.0 mmol/L; group B, 8.0mmol/L≤FPG11.0 mmol/L, group C, FPG≥11.0 mmol/L）. The liver function and blood lipids were detected, then analysis for the influence and statistical significance between liver function, blood lipid and type Ⅱ diabetes mellitus patients＇ blood glucose level were performed by SPSS 17.0. Results： Compared with group A and group B, group C was more obvious in the rise of ALT, AST（P〈0.05）, characterized by a significant rise in liver enzymes and bilirubin（P〈0.05）,and GLB level had significant increase（P〈0.05）; TC and TG level were abnormal（P〈0.05）. Conclusions： TypeⅡ diabetes mellitus patients with higher blood glucose level can cause more serious liver damage and dyslipidemia. The surveillance and control of blood glucose have an important significance for the health of the typeⅡ diabetes mellitus patients.

关 键 词：糖尿病 肝功能 血脂 

分 类 号：R587.1[医药卫生—内分泌]