神经肽CGRP、SP、NPY对软骨细胞的影响研究  

Impact of Neuropeptide CGRP, SP, NPY on Chondrocytes

作　　者：夏先学[1] 蒋萍[1] 陈路[1] 宋超敏[1] 蔚芃[1] 

机构地区：[1]川北医学院附属医院骨科,四川南充637000

出　　处：《现代生物医学进展》2015年第17期3370-3373,共4页Progress in Modern Biomedicine

摘　　要：近年来,由于创伤和感染等多类原因导致的骨折和骨不连等症状均是威胁到人类生命安全及生活质量的一个医学难题,为了更好地提升对于此类患者的治疗效果,有必要明确骨形成和重建等病理生理学情况以及相应的生物学机制。同时,骨组织是一类随细胞外基质的矿化,并根据其自身需求进行修复的动态组织,也是有着血管和神经支配的活性组织,所以,骨折的修复过程当中不仅含机体各类组织和细胞因子间的复杂作用,还和血液供应及神经支配紧密相连。目前,临床关于神经肽的研究逐渐增多,且越来越多的报道表明神经肽类物质能够在骨折愈合及重建过程中发挥出重要作用,原因可能和机体神经发挥相应的调控作用,并刺激骨细胞发生变化等因素有关。本文即据此展开关于神经肽CGRP(降钙素基因相关肽,Calcitonin gene-related peptide)、SP(P物质,Substance P)、NPY(神经肽Y,Neuropeptide Y)对软骨细胞影响情况的综述分析,从而更好地服务临床。In recent years, bone fractures and nonunion caused by various factors such as trauma and infection were all medical problems that threatened human safety and quality of life, in order to promote the therapeutic effect for such patients, there was a need to clarify the pathophysiology as well as the corresponding biological mechanisms of bone formation and renewal. Bone tissue is a type of extracellular matrix mineralization, and can repair itself according to its own needs dynamically, bones also had blood vessels and nerve tissue activity, so the repair process of fractures not only consist of complex role of cytokines of various organizations but also of nerve and blood supply. Currently, clinical research on neuropeptides gradually increased, and a growing number of reports indicated that neuropeptides healing and rebuilding process could play an important role in the fracture, probably due to the body＇s nerves and they also play a relevant role in regulating and stimulating bone cells and other factors change. This paper accordingly review on the impact of neuropeptide CGRP（calcitonin gene-related peptide, Calcitonin gene-related peptide）, SP（P substance, Substance P）, NPY（neuropeptide Y,Neuropeptide Y） on chondrocytes in order to serve the clinic better.

关 键 词：神经肽 CGRP SP NPY 软骨细胞 影响研究 

分 类 号：R68[医药卫生—骨科学]