米非司酮预处理后行宫腔镜子宫黏膜下肌瘤切除术的效果分析  

Clinical analysis of mifepristone and transcervical resection of myoma in patients with submucous myoma

作　　者：黎普茜[1] 陈健华[1] 李栩萍[1] 叶艳娜 

机构地区：[1]东莞市人民医院妇产科,广东东莞523000 [2]广东省东莞卫生学校,广东东莞523186

出　　处：《医药前沿》2015年第11期53-55,共3页Journal of Frontiers of Medicine

摘　　要：目的：探讨米非司酮预处理后行宫腔镜子宫肌瘤切除术治疗子宫黏膜下肌瘤临床效果和安全性。方法：随机将2011年1月至2014年12月在我院治疗的103例黏膜下I、Ⅱ型子宫肌瘤患者分为A组（研究组）55例和B组（对照组）48例。A组患者给予米非司酮口服治疗3个月后行宫腔镜电切术治疗，B组直接行宫腔镜电切术治疗，比较米非司酮预处理前后A组患者情况及A、B两组患者的临床效果。结果：服用米非司酮预处理3个月后A组患者月经期时间短于服药前，月经量少于服药前，子宫体积和肌塘体积小于服药前，血红蛋白高于服药前，差异均有统计学意义（P〈0．05）。A组平均手术时间、术中出血量、术前术后输血率、平均住院天数、平均住院费用均低于B组，差异均有统计学意义（P〈0．05）。A组治愈率高于B组，A组无效率低于B组，差异均有统计学意义（P〈0．05）。结论：米非司酮预处理后行宫腔镜子宫肌瘤切除术治疗黏膜下子宫肌瘤较有效、安全，值得在临床推广。Objective To investigate the clinical efficacy and safety of transcervical resection of myoma in patients with submucons myoma. Methods The clinical data of 103 patients with type I and type Ⅱ of submucous myoma who were treated in the department of gynaecology and obstetrics in our hospital from January 2011 to December 2012 were collected.These patients were divided into group A and group B by using a random number table, and group A was given mifepristone for 3 monthes before operation, patients in group A was given tmnscervical resection of myoma for treatment, the occurrence of adverse drug and the clinical efficacy reactions was evaluated. Results After taking mifepristone for 3 monthes, menstrual period of group A is shorter, menstrual blood volume is less,the volume of the uterine and myoma is samller, the number of hospitalization is higher, and the difference was statistically significant（P 〈 0.05）. The average operation time, bleeding amount in operation, the case of preoperative and postoperative blood transfusion, hospitalization days, cost of hospitalization of group A were lower than the group B, and the difference was statistically significant（P 〈 0.05）. The total cure rate of group A is higher than the group B, the ineffective rate of of group Ais lower than the group 13, and the difference was statistically significant（P 〈 0.05）. Conclusions Mifepristone and transcervical resection of myoma can obtain satisfactory curative effect for patients with patients with submucous myoma ,it is effective and reliable, it is worthy of clinical application.

关 键 词：宫腔镜电切术 米非司酮 黏膜下子宫肌瘤 

分 类 号：R453[医药卫生—治疗学]