人参皂苷Rg3固体分散体的制备及表征  

Preparation and Characterization of Ginsenoside Rg3 Solid Dispersion

作　　者：李健莹 栾晓娇 王凯乾 张迪[1] 于秀[1] 胡美娜[1] 富力 周晓霞[1] 徐缓[1] 

机构地区：[1]辽宁师范大学化学化工学院,辽宁大连116029 [2]大连富生天然药物开发有限公司,辽宁大连116600

出　　处：《中国药学杂志》2015年第10期872-875,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81102394);中国博士后科学基金(2013M530899)

摘　　要：目的尝试采用一种新型技术制备人参皂苷Rg3固体分散体,从而提高脂、水难溶药物人参皂苷Rg3的溶解性。方法以醋酸羟丙基甲基纤维素琥珀酸酯为载体制备人参皂苷Rg3固体分散体,利用傅立叶变换近红外光谱、X-射线衍射、差示量热扫描分析及扫描电子显微镜等分析方法表征人参皂苷Rg3固体分散体。利用高效液相色谱法分别测定了人参皂苷Rg3和人参皂苷Rg3固体分散体的平衡溶解度。结果人参皂苷Rg3固体分散体可以增加药物的溶解度,在模拟人十二指肠和空肠p H的条件下人参皂苷Rg3固体分散体的溶解性能显著优于原料药。结论本实验制备人参皂苷Rg3固体分散体的方法操作简单、经济实用,增加人参皂苷Rg3溶解度的效果显著。OBJECTIVE To prepare ginsenoside Rg3（ G-Rg3） solid dispersion by atoping a new technology to increase the solubility of G-Rg3. METHODS Hydroxypropyl methylcellulose acetate succinate（ HPMCAS） was selected as the carrier to prepare GRg3 solid dispersion. The G-Rg3 solid dispersion was characterized via Fourier transform infrared spectroscopy,X-ray diffractometry,differential scanning calorimetry analysis,and scanning electron microscopy. The equilibrium solubility of G-Rg3 and G-Rg3 solid dispersion were measured by using high-performance liquid chromatography. RESULTS The G-Rg3 solid dispersion was successfully prepared. The solubility of G-Rg3 solid dispersion in the weak acid medium（ p H 5. 5 and 6. 4） designed to simulate human duodenum and jejunum was significantly higher than that of G-Rg3. CONCLUSION The preparation method of G-Rg3 solid dispersion is simple,economic,and practical,which can obviously increase the of solubility of G-Rg3.

关 键 词：人参皂苷RG3 固体分散体 醋酸羟丙基甲基纤维素琥珀酸酯 溶解度 

分 类 号：R944[医药卫生—药剂学]