右美托咪定联合盐酸羟考酮对食管癌手术患者麻醉苏醒期躁动的影响  

Effects of dexmedetomidine combined with oxycodone hydrochloride on emergence agitation of patients with esophageal cancer

作　　者：李晶[1,2] 范钦[3] 卢飞飞[3] 刘磊[3] 乔伟丽[3] 殷琴[3] 程伟[3] 闫长栋[3] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室/江苏省麻醉与镇痛应用技术重点实验室,江苏徐州221004 [2]徐州医学院第二附属医院,江苏徐州221006 [3]徐州医学院生理学教研室,江苏徐州221004

出　　处：《徐州医学院学报》2015年第5期294-297,共4页Acta Academiae Medicinae Xuzhou

基　　金：国家自然科学基金（31100801,81200858）

摘　　要：目的研究右美托咪定联合盐酸羟考酮对食管癌手术患者麻醉苏醒期躁动的影响。方法入选食管癌手术患者50例，随机分为盐酸羟考酮组（A组）、右美托咪定联合盐酸羟考酮组（B组），术后采用患者自控镇痛（PCA），并记录麻醉诱导前（T1）及拔管后1h（T2）、6h（T3）、12h（T4）、24h（T5）时的收缩压（SBP）、舒张压（DBP）、心率（HR）、脉搏氧饱和度（SpO2）及各组的术后躁动发生率、Ramsay评分及疼痛视觉模拟评分（VAS）情况。结果2组患者一般情况无明显差异（P〉0．05）；和A组比较，B组患者Ramsay评分增高（P〈0．05），VAS评分和躁动发生率减低（P〈0．05）。结论右美托咪定联合盐酸羟考酮用于开胸食管癌术后镇痛可使患者苏醒期安静合作，明显减少麻醉苏醒期躁动发生率。Objective To investigate the effects of oxycodone hydrochloride and dexmedetomidine on emergence agitation of patients with esophageal cancer after anesthesia. Methods Fifty ASA grade Ⅰ - Ⅱpatients undergoing esophageal cancer operation were randomly divided into two groups： an oxycodone hydrochloride group （group A） and a dexmedetomidine and oxycodone hydrochloride group （ group B） , with 25 patients in each group. After surgery, patient - controlled analgesia was provided. The systolic blood pressure （SBP）, diastolic blood pressure （DBP）, heart rate （HR）, blood oxygen saturation （ SpO2 ）, the incidence of agitation, VAS score and Ramsay sedation score were recorded at the following time points ： before induction of anesthesia （ T1 ） , 1 hour after operation （ T2 ） , 6 hours after operation （ T3 ） 12 hours after operation （ T4 ）, and 24 hours after operation （ T5 ）. Results There was no significant difference between the two groups in their general condition （P 〉 0.05 ）. Compared with Group B, patients in Group A produced higher Ramsay scores, VAS scores and lower agitation rates （ P 〈 0. 05 ）. Conclusion Oxyeodone hydrochloride combined with dexmedetomidine can significantly reduce the incidence of emergence agitation, which can be applied for postoperative analgesia for esophageal cancer patients after operation.

关 键 词：右美托咪定 盐酸羟考酮 术后镇痛 术后躁动 

分 类 号：R614.2[医药卫生—麻醉学]