注射用阿莫西林钠克拉维酸钾溶液的稳定性研究  

Stability Explore Injection Amoxicillin Clavulanate Potassium Sodium Solution

作　　者：李彩兰[1] 张涛[1] 郭杨庆 

机构地区：[1]南雄市人民医院药剂科,广东韶关512400

出　　处：《中国药物经济学》2015年第5期20-22,共3页China Journal of Pharmaceutical Economics

摘　　要：目的探讨注射用阿莫西林钠克拉维酸钾溶液在不同溶剂配伍使用时的稳定性。方法用高效液相色谱法（HPLC）测定配液后阿莫西林钠克拉维酸钾在不同时段的含量变化情况,并观察配液后颜色变化情况。结果注射用阿莫西林钠克拉维酸钾在0.9%氯化钠注射液中的稳定性较好,在3 h内药物有效含量下降小于10%;但在葡萄糖注射液中的稳定性较差,在用药3 h内药物有效含量下降在10%-30%。结论注射用阿莫西林钠克拉维酸钾在0.9%氯化钠注射液中的稳定性较好,但在含葡萄糖溶液中的稳定性相对较差,且其含量下降速度与葡萄糖含量呈正比,用0.9%氯化钠注射液溶解后应立即稀释,并应在3 h内（25℃以下）完成整个输液过程。Objective To explore the injection of sodium amoxicillin and clavulanate potassium solution stability compatibility when using different solvents.Methods Determination of the dosing by high performance liquid chromatography（HPLC）amoxicillin clavulanate potassium sodium content changes in different time periods,and observe the color changes after dosing.Results For injection amoxicillin sodium clavulanate potassium is preferably stable in 0.9% sodium chloride solvent,in a pharmaceutically effective 3h decreased less than 10%;in glucose- containing solvent stability than difference,in a pharmaceutically effective drug 3 h decreased about 10% -30% Conclusion Amoxicillin sodium injection stability of potassium clavulanate in 0.9% sodium chloride solution is preferably, but in the glucose-containing solution is relatively poor stability, and the rate of decline in an amount proportional to the glucose content,immediately after dilution with 0.9% sodium chloride injection solution,and should be complete within 3 h infusion process （25 ℃ below）.

关 键 词：注射用阿莫西林钠克拉维酸钾 溶液 稳定性 

分 类 号：R927.1[医药卫生—药学]