妊娠期高血压疾病对足月新生儿脂代谢及胆红素代谢的影响  

Effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates

作　　者：田淑新[1] 王丽娟[1] 

机构地区：[1]唐山市妇幼保健院产二科,河北省唐山063000

出　　处：《中国基层医药》2015年第9期1306-1308,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：河北省唐山市科技计划课题（06134601a-14）

摘　　要：目的 观察妊娠期高血压疾病对足月新生儿脂代谢及胆红素代谢的影响.方法 选取足月新生儿200例,其中母亲健康者100例（对照组）,母亲患有妊娠期高血压疾病者100例（观察组）,记录婴儿出生体质量,测定脐血三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、脂联素（APN）水平,监测经皮胆红素（TCB）,记录出生24 h、48 h、72 h TCB值及峰值.结果 观察组体质量为（2 927±492）g,低于对照组的（3 452±348）g,低体质量发生率高于对照组（χ2=25..48,P＜0.01）;观察组TG、LDL-C水平分别为（0.6±0.24） mmol/L、（1.95±0.25） mmol/L,高于对照组[TG、LDL-C分别为（0.39 ±0.17） mmol/L、（1.95 ±0.25） mmol/L]（t=12.35、2.35,均P＜0.05）.观察组HDL-C、APN水平分别为（0.64±0.19）mmol/L、（53.1±12.7）mg/L,低于对照组[HDL-C、APN水平分别为（0.85±0.27） mmol/L、（64.3±10.2） mg/L]（t=1.79、7.00,均P＜0.05）;观察组出生24h、48 h、72 h胆红素值、胆红素峰值分别为（8.64±2.17） mg/L、（11.06±3.12） mg/L、（10.32±2.47） mg/L、（12.04±2.13） mg/L,高于对照组[24 h、48h、72 h胆红素值、胆红素峰值分别为（3.06±0.94） mg/L、（6.98±1.56） mg/L、（7.26±1.89） mg/L、（9.64±1.98）mg/L],差异均有统计学意义（t=23.48、11.65、9.84、8.27,均P＜0.01）.结论 妊娠期高血压疾病导致足月新生儿出生体质量较低,并影响新生儿的胆红素代谢及脂代谢.Objective To observe the effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates.Methods 200 term neonates were selected and divided into the two groups,100 cases whose mother were healthy were control group and another 100 cases whose mother had gestational hypertension were observation group.Birth weight,measured in cord blood triglyceride （TG）,total cholesterol （TC） levels,high density lipoprotein （HDL-C）,low density lipoprotein （LDL-C）,adiponectin （APN） level were recorded.Results Birth weight of the observation group had significantly lower birth weight （2 927 ± 492） g,than the weight of the control group （3 452 ± 348） g.The incidence of lower birth weight was higher than in the observation group.TG,LDL-C levels of the observation group were （0.6 ± 0.24） mmol/L,（1.95 ± 0.25） mmol/L,were higher than those of the control group[（0.39 ± 0.17） mmol/L,（1.95 ± 0.25） mmol/L].There was a statistically significant difference between the groups （t =12.35,2.35,P 〈 0.01 or P 〈 0.05）.HL-C and APN of the observation group were lower than those of the control group （t =1.79,7.00,all P 〈 0.05）.Bilirubin after bomed 24 hours,48 hours,72 hours and bilirubin peak of the observation group were （8.64 ± 2.17） mg/L,（11.06 ± 3.12） mg/L,（10.32 ± 2.47） mg/L,（12.04 ± 2.13） mg/L and were higher than those of the control group [（3.06 ± 0.94） mg/L,（6.98 ± 1.56） mg/L,（7.26±1.89）mg/L,（9.64±1.98）mg/L]（t=23.48,11.65,9.84,8.27,allP〈0.01）.Conclusion Maternal PIH may affect birth weight,lipid metabolism and bilirubin metabolism.

关 键 词：妊娠期高血压疾病 婴儿 新生 血脂 胆红素 

分 类 号：R714.7[医药卫生—妇产科学]