大肠埃希菌和铜绿假单胞菌的耐药性分析  

Analysis on drug resistance of Escherichia coli and Pseudomonas aeruginosa

作　　者：刘莉[1] 徐婷婷[1] 

机构地区：[1]湖北医药学院附属随州医院药学部,湖北随州441300

出　　处：《中国医院药学杂志》2015年第10期952-957,共6页Chinese Journal of Hospital Pharmacy

基　　金：湖北省自然科学基金(编号:2009CDB186)

摘　　要：目的:通过分析临床标本中大肠埃希菌和铜绿假单胞菌的分布及耐药性,了解细菌耐药性的变化趋势以及2种细菌的耐药率与抗菌药物用药频度的相关性,认识细菌耐药性变化与抗菌药物使用之间的关系。方法:调查某医院2009年至2013年临床标本中分离出的大肠埃希菌和铜绿假单胞菌,采用SPSS 17.0软件分析2种细菌耐药率与抗菌药物用药频度的相关性。结果:细菌耐药率与多种抗菌药物用药频度的关系较为复杂,但存在相关性。结论:所研究医院的大肠埃希菌及铜绿假单胞菌对于常用抗菌药物的耐药率高并与抗菌药物的用药频度有一定关系。因此,在临床工作中应严谨的使用抗菌药物以降低抗菌药物的用量,从而有效控制细菌耐药性的进展。OBJECTIVE To investigate the drug resistance of Escherichia coli and Pseudomonas aeruginosa, by analyzing distribution and drug resistance of them as well as relationship between drug resistance and DDDs to conclude the connection of between them. METHODS Escherichia coli and Pseudomonas aeruginosa were separated from clinical samples from 2009 to 2013. SPSS was employed to analyze the relationship between drug resistance of bacteria and DDDs. RESULTS Although the relationship between drug resistance of bacteria and DDDs was complex, the correlation was obvious. CONCLUSION The drug resistance of Escherichia coli and Pseudomonas aeruginosa in the studied hospital is frequent, which may be correlated with DDDs of antibacterial agents. The use of antibacterial agents should be more rigorously controlled during clinical practice to decrease DDDs of antibacterial agents and to efficiently control progress of drug resistance of bacteria.

关 键 词：大肠埃希菌 铜绿假单胞菌 细菌耐药性 抗菌药物 用药频度 相关性 

分 类 号：R969[医药卫生—药理学]