PVA/HA复合双层水凝胶的制备及性能研究  

Preparation and Properties of PVA/HA Composite Double Layer Hydrogel

作　　者：沈艳秋[1] 陈凯[2] 戴祖明[2] 

机构地区：[1]金陵科技学院,南京211169 [2]中国矿业大学材料科学与工程学院,徐州221116

出　　处：《材料导报》2015年第10期73-77,共5页Materials Reports

基　　金：教育部高等学校博士学科点专项科研基金(20110095110001)

摘　　要：以聚乙烯醇(PVA)、羟基磷灰石(HA)为原料,利用铸造干燥法与冷冻解冻法制备双层仿生软骨,并进行力学性能测试。结果表明:PVA/HA复合双层水凝胶力学性能优于PVA/HA复合水凝胶。利用铸造干燥法,PVA与HA间的交联结合将更加完善,力学性能得到提升。最优的PVA/HA复合双层水凝胶是采用铸造干燥法用PVA浓度为12%的溶液所制备出的双层水凝胶,其压缩弹性模量为(1.29±0.025)MPa,900s时应力松弛达到(60.14±0.64)%,最大形变和永久形变为(246.3±3.05)μm和(69.8±2.96)μm。Through casting drying method and freeze-thaw method, polyvinyl alcohol （PVA） and hydroxyapa- tite （HA） were used as raw materials to prepare double layer bionic cartilage, whose mechanical properties were stu- died by testing. Results showed that mechanical properties of PVA/HA composite double layer hydrogel were better than PVA/HA composite hydrogel. The crosslink between PVA and HA would be improved through casting drying method, causing improved mechanical properties. The optimal PVA/HA composite double layer hydrogel could be ob- tained at a concentration of 12% PVA solution through casting drying method. Its compression elastic modulus was （1.29±0. 025） MPa, and stress relaxation reached to （60. 14±0. 64）% at 900 s, with a maximum deformation of （246.3±3. 05） μm and a permanent deformation of （69.8!2.96） μm, respectively.

关 键 词：聚乙烯醇 羟基磷灰石 铸造干燥法 冷冻解冻法 双层仿生软骨 

分 类 号：Q811.7[生物学—生物工程]