栀子苷对非酒精性脂肪性肝病金黄地鼠脂质代谢及炎症损伤的影响  

Effect of geniposide on the lipid metabolism and inflammatory injury of nonalcoholic fatty liver disease in the hamster

作　　者：李国辉[1] 周海虹[1] 赵正晓[1] 张玉梅[1] 柳进[1] 陈少东[1] 

机构地区：[1]厦门大学医学院,福建厦门361102

出　　处：《中国中医基础医学杂志》2015年第5期524-525,541,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金面上项目(81274155);厦门市重大科技计划项目(3502Z20100006)

摘　　要：目的:观察栀子苷对高脂饮食诱导的金黄地鼠非酒精性脂肪性肝病模型脂质代谢、肝组织病理变化及炎症损伤的影响,并与栀子进行比较,以明确栀子抗脂肪肝作用的效应成分。方法:24只雄性金黄地鼠按随机数字表法分为正常组、模型组、栀子组和栀子苷组。实验后观察肝组织病理学变化,并检测肝组织TG含量、血清TG、CHO含量及ALT、AST活性。结果:与模型组比较,栀子组、栀子苷组肝TG含量、血清TG、CHO含量及ALT、AST活性均显著降低,且栀子苷对ALT、AST活性的降低作用优于栀子。结论:栀子苷与栀子对高脂饮食诱导的地鼠脂肪肝均有显著干预作用,且栀子苷抗炎症损伤作用优于栀子。Objective：To observe geniposide＇ s effect on lipid metabolism, hepatic tissue pathological change and inflammatory injury of golden hamsters with nonalcoholic fatty liver disease（ NAFLD）, caused by high fat diet. Compare the geniposide＇ s effect with gardenia to make clear the effective components in Gardenia that can resist fatty liver. Methods：24 male golden hamsters were averagely divided into control group, model group, gardenia group and geniposide group. The experiment was based on building the model, and then observe hamsters＇ general condition and pathological change of hepatic tissue, examine the content of hepatic tissue TG, serum TG, CHO and the activity of ALT, AST. Results： In gardenia group and gardenoside group, The content of hepatic tissue TG, serum TG, CHO and the activity of ALT, AST are significantly lower than the model group. Besides, gardenoside can lower the activity of ALT, AST better than gardenia. Conclusion：Both gardenoside and gardenia have notable intervention effects on hamsters＇ NAFLD caused by HFD and gardenoside have better effects on resisting inflammatory injury than gardenia, which suggested that gardenoside was the primary effective component in resisting NAFLD.

关 键 词：栀子 栀子苷 非酒精性脂肪性肝病 金黄地鼠 

分 类 号：R285.5[医药卫生—中药学]