不同海拔高度对睡眠呼吸暂停低通气综合征患者的影响  

The effect of different elevation on the patients with sleep apnea-hypopnea syndrome

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作  者:何忠明[1] 叶舟[1] 李剑平[1] 张庆龙[1] 石娟[1] 李敏[1] 雷清生[1] 韩芳[2] 

机构地区:[1]新疆维吾尔自治区克拉玛依市中心医院呼吸科,834000 [2]北京大学人民医院呼吸内科,100044

出  处:《国际呼吸杂志》2015年第10期742-745,共4页International Journal of Respiration

基  金:国家自然科学基金资助项目(81360016);克拉玛依市科技经费资助项目(JK2013-18)

摘  要:目的:探讨不同海拔高度对睡眠呼吸暂停的影响。方法应用便携式睡眠呼吸监测仪测定5名受试者(均为睡眠呼吸暂停患者)在不同海拔高度(500 m、1000 m、2261 m、2800 m、3650 m、4200 m)下的夜间呼吸、脉搏、动脉氧饱和度及晨起血压。结果与海拔500 m 相比,当海拔升至4200 m时,患者睡眠时的呼吸暂停低通气指数、氧减指数、低通气指数均升高[(28.6±11.3)次/h vs (11.0±5.4)次/h;(29.8±11.0)次/h vs (11.2±5.2)次/h;(19.6±9.0)次/h vs (7.6±3.4)次/h,P 值均〈0.05]。不同海拔组间患者的其它指标如平均动脉氧饱和度、最低动脉氧饱和度、收缩压、舒张压等的变化也均有统计学意义(P 值均〈0.05)。结论高海拔对睡眠呼吸紊乱的影响以中枢性睡眠呼吸暂停和低通气增高为主,应重视高海拔对睡眠呼吸暂停的影响。Objective To explore the effect of different altitude on the patients with sleep apnea-hypopnea syndrome.Methods Five subjects underwent respiration and pulse oximeter tests.Apnea-hypopnea index (AHI),hypopnea index (HI),mean saturation of arterial blood oxygen (MSaO2 ),the lowest saturation of arterial blood oxygen (LSaO2 ),the time spent at SaO 2 below 90% (SIT90 ),the number of desaturations≥4% per hour(ODI4 )and blood pressure were calculated at different altitude (include 500 m,1 000 m,2 261 m,2 800 m,3 650 m and 4 200 m).Results The apnea-hypopnea index, hypopnea index,oxygen desaturation index,MSaO 2 ,LSaO 2 ,systolic pressure and diastolic pressure were significantly different among five different altitude groups (all P〈0.05).The AHI rised from (1 1.0 ± 5.4)times/h to (28.6±1 1.3)times/h,the HI rised from (7.6±3.4)times/h to (1 9.6 ±9.0)times/h and ODI4 rised from (1 1.2±5.2)times/h to (29.8±1 1.0)times/h as altitude increases from 500 m to 4 200 m.Conclusions The influence of highter altitude on the respiratory function are predominantly central apneas and hypopneas.We should pay attention the effects of high altitude on the sleep apnea.

关 键 词:睡眠呼吸紊乱 海拔 

分 类 号:R766[医药卫生—耳鼻咽喉科]

 

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