自拟中药药方联合两种药物治疗功能性消化不良患者的疗效研究  

The Research on the Efficacy of Combination of Two Traditional Chinese Medicine Prescription Medication in Patients with Functional Dyspepsia

作　　者：周继旺[1] 

机构地区：[1]丽水市中医院消化科,浙江丽水323000

出　　处：《中华中医药学刊》2015年第6期1369-1371,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81000157)

摘　　要：目的:探究自拟中药药方联合两种药物治疗功能性消化不良患者的疗效。方法:选取2012年1月—2014年6月收治的86例功能性消化不良患者作为此次研究对象,按照随机数表法随机抽取组成研究组和对照组,每组43例,对照组采用阿嗪米特肠溶片,饭后服用,每日3次,每次2片和马来酸曲美布汀胶囊,饭后服用,每日3次,每次1粒进行治疗;研究组在治疗组的基础上加用医院自拟中药药方(枳壳10 g,柴胡10 g,陈皮10 g,大腹皮10 g,延胡索10 g,苏梗10 g,香附子10 g,脾弱痰湿患者加党参15 g,半夏10 g,茯苓10 g,白术10 g,厚朴10g;脾虚弱者加党参15 g,白木10 g,茯苓10 g;伴随明显抑郁患者加合欢皮10 g,郁金10 g,寒热交错者加吴茱萸5g,清半夏10 g,黄连5 g,乌贼骨15 g,频繁嗳气患者增加旋覆花15 g)每日1剂,早晚服用联合治疗。两组均治疗2个疗程后,进行疗效比较。结果:比较两组治疗后单一症状的疗效,结果显示,研究组腹胀腹痛、恶心反胃、食欲不振和早饱方面的显效和总有率高于对照组(P<0.05),无效率低于对照组(P<0.05);比较两组患者治疗后总疗效,结果显示,研究组治疗功能性消化不良的显效率和总有效率高于对照组(P<0.05),无效率低于对照组(P<0.05);比较两组患者治疗前后临床症状积分,结果显示,两组比较治疗前,症状积分均有下降(P<0.05),研究组治疗后积分比对照组治疗后积分低(P<0.05),两组患者治疗前症状积分无统计学差异(P>0.05);治疗过程中,两组均有1例患者出现口渴症状,对照组患者出现1例犯困。结论:自拟中药药方联合两种药物治疗功能性消化不良疗效显著,安全,值得一定的临床推广意义。Objective ：To explore the self- made prescription medicine combined effect of the two drugs in patients with functional dyspepsia. Methods ：86 cases of patients with functional dyspepsia were selected from our hospital in Janu- ary 2012- June 2014 as the research object, according to a random number table method, were randomly divided into study group and the control group,43 cases in each group. The control group used azintamide enteric coated tablets after meal,3 times a day,2 tablets each time and trimebutine maleate capsules after meal, 3 times a day, 1 capsule each time for treatment ; research group based on treatment group with self - made traditional Chinese medicine prescriptions in our hospital （ Fructus aurantii, bupleurum, dried orange peel, Pericarpium Arecae, Rhizoma Corydalis, perilla stem, Cyperus rotundus each 10 g, weak spleen phlegm dampness patients with dangshen 15 g, pinellia, Poria magnolia, white wood, each 10 g; spleen weak add dangshen 15 g ,white wood, Poria cocos 10 g; with obvious depressive patients with bark of silktree and turmeric each 10 g, alternating cold and heat, plus Evodia 5 g, Rhizoma Pinelliae10 g, Rhizoma Coptidis 5 g, cuttle- fish bone 15 g, frequent belching patients increased inula flower 15 g） daily, morning and evening taking the combined therapy. The two groups after 2 courses of treatment, the curative effect comparison was made. Results ： The curative effects of two groups were compared after treatment. The study group abdominal distention, nausea, loss of appetite and satiety as- pects markedly and the total rate was higher than that of the control group （ P 〈 0.05 ）, no efficiency was lower than that of the control group （P 〈 0.05 ） ; the total effect after treatment, the results showed the study group functional dyspepsia significant efficiency and the total efficiency was higher than that of the control group （ P 〈 0.05 ）, no efficiency was lower than that of the control group （P 〈 0.05 ） ; the two groups before and after tre

关 键 词：功能性消化不良 中药 阿嗪米特肠溶片 马来酸曲美布汀胶囊 

分 类 号：R975[医药卫生—药品]