新疆维吾尔族、汉族原发性高血压患者ACE多态性分析  

Essential hypertension patients' ACE gene polymorphism in the Uighur and Han people of Xinjiang

作　　者：赖艳娴 郭宝云[2] 邓聪 阿不都热西提.则亚维丁 刘城[3] 陈文忠 刘凯 

机构地区：[1]广州市南沙中心医院,广州511400 [2]新疆维吾尔自治区喀什地区疏附县人民医院,喀什844000 [3]广州市第一人民医院心内科,广州510180

出　　处：《广州医药》2015年第3期12-15,共4页Guangzhou Medical Journal

基　　金：新疆维吾尔自治区自然科学基金(201318101-12)

摘　　要：目的研究血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与新疆地区维吾尔族(维族)、汉族人群原发性高血压(EH)的关系。方法采用聚合酶链反应(PCR)检测此两类人群104例原发性高血压(病例组、EH)及102例健康人群(对照组、NT)血中ACE基因16号内含子的I/D多态性。统计各基因型频率、等位基因频率,并采用Logistic回归分析剔除混杂因素后ACE基因I/D多态性与EH的关系。结果两族人群的EH组与NT组D等位基因频率及基因型频率差异均没有统计学意义(P>0.05)。但经Logistic回归分析校正各种混杂因素后,两族人群EH的发病率与ACE基因(I/D)多态性相关(P<0.05)。结论 ACE基因I/D多态性可能为新疆地区维族、汉族EH的易感因素。Objective To investigate whether the insertion deletion （I/D） polymorphism in the angiotensin converting enzyme （ACE） gene is associated with essential hypertension （EH） in Uighur and Han population of Xinjiang. Methods The study covered 104 hypertension patients （EH） and 102 normotensive controls （NT）. The variant of ACE I/D was deter- mined by polymorphism chain reaction （PCR）. Logistic was used to analyze the ACE I/D polymorphism compared with ACE genotype. Results There was no significant difference between the EH and NT group about the genotype frequency and allele frequency （P 〉 0. 05 ）. Using logistic regression analysis, adjusted for confounding factor, there was a relationship between EH and ACE gene I/D polymorphism （P 〈 0. 05 ）. Conclusion The results suggest that the I/D polymorphism of ACE gene is associated with the EH in the Uighur and Han people of Xinjiang.

关 键 词：血管紧张素转换酶(ACE) 高血压 多态性 维吾尔族 汉族 

分 类 号：R544.1[医药卫生—心血管疾病]