糖化血红蛋白联合超敏C反应蛋白在筛查妊娠期糖尿病的价值  

Combination of Hb A1c and hs-CRP examination in screening of gestational diabetes mellitus

作　　者：江玉娥[1] 丘媚妮[1] 陈海英[1] 梁小花[1] 张映霞[1] 

机构地区：[1]嘉应学院医学院附属医院妇产科,广东梅州514031

出　　处：《广州医药》2015年第3期44-46,共3页Guangzhou Medical Journal

摘　　要：目的探讨糖化血红蛋白(Hb A1c)联合超敏C反应蛋白(hs-CRP)在筛查妊娠期糖尿病(GDM)的临床意义。方法选择2013年9月1日—2014年8月31日在我院妇产科孕期产前检查及分娩的孕妇,根据糖耐量试验(OGTT)、Hb A1c和hs-CRP检查,筛查出92例孕妇为GDM组,并随机抽取OGTT正常的健康孕妇90例为NGT组,25例健康孕龄女性为对照组,分析3组FPG、Hb A1c、hs-CRP及OGTT结果。结果 GDM组OGTT、Hb A1c、hs-CRP高于NGT组和对照组,差异有统计学意义(P<0.01),NGT组与对照组比较,Hb A1c、hs-CRP浓度差异无统计学意义(P>0.05),但3组FPG差异无统计学意义(P>0.05),Pearson相关分析显示,Hb A1c与hs-CRP呈正相关(r=0.79,P<0.01)。结论GDM患者Hb A1c、hs-CRP水平升高,Hb A1c联合hs-CRP可能成为GDM筛查的良好指标。Objective To evaluate the feasibility of combination of glycosylated hemoglobin Ale（I-IbAlc） and high-sen- sitivity CRP in screening of gestational diabetes mellitus （GDM）. Methods According to glucose tolerance test （ OGTT）, HbAlc and hs-CRP during 24 -28 pregnant weeks, 92 women with GDM （GDM group） and 90 normal pregnant women （NGT group） were enrolled in this study with another 25 women of child-bearing age as the control group. The results of FBG, OGTT, HbAlc and hs-CRP among three groups were analyzed. Results OGTT, HbAlc and hs-CRP level in GDM group were higher than that in NGT group and control group （ P 〈 0. 05 ）, but there were no significant differences of the level of FPG of 3 groups （ P 〉 0. 05 ）. Compare with NGT group and control group, There were no significant differences of the level of HbA1c and hs-CRP（P 〉0. 05）. Pearson correlation analysis showed that HbAlc had significant association with hs-CRP （r =0. 79, P 〈0. 01 ）. Conclusion HbAlc and hs-CRP level in GDM group were increased, HbA1 c combined with hs-CRP could be of some value in screening of GDM.

关 键 词：妊娠期糖尿病 糖化血红蛋白 超敏C反应蛋白 

分 类 号：R714.256[医药卫生—妇产科学]