4-磺酰胺基苯肼盐酸盐的合成研究  

The Study of Synthesis for 4-Sulfonamidophenylhydrazine Hydrochloride

作　　者：俞传明[1] 石教勇 潘灵灵 王亚敏[1] 

机构地区：[1]浙江工业大学药学院长三角绿色制药协同创新中心,浙江杭州310014

出　　处：《浙江化工》2015年第5期19-21,共3页Zhejiang Chemical Industry

摘　　要：主要研究了由磺胺经重氮化反应合成4-磺酰胺基苯肼盐酸盐,考察了重氮盐还原反应中温度、Na2SO3投料量,对磺酰胺基苯肼成盐时盐酸用量对反应及产率的影响;同时考察了管式反应在4-磺酰胺基苯肼盐酸盐合成中的应用。The synthesis of reducing sulfanilamide via diazotization to 4-sulfonamidophenylhydrazine hydrochloride was dealt with. The effect of the factors on the reaction were discussed, such as the reaction temperature, the amount of sodium sulfite and the hydrochloric acid. The method of pipeline reaction in 4-sulfonamidophenylhydrazine hydrochloride preparing process was also investigated.

关 键 词：管式反应 4-磺酰胺基苯肼盐酸盐 重氮化 磺胺 

分 类 号：O621.3[理学—有机化学] TQ460.1[理学—化学]