积雪草等3种挥发油对盐酸氟西汀体外经皮渗透性的影响  

Effects of Three Kinds of Volatile Oils on Percutaneous Transport of Fluoxetine Hydrochloride in vitro

作　　者：李圣惠[1] 黄家富[2] 丁青龙[2] 祖强[1] 李杰[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]中国人民解放军第102医院药械科,江苏常州213003

出　　处：《南京中医药大学学报》2015年第3期265-268,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省"青蓝工程"创新团队支持计划资助

摘　　要：目的考察不同浓度积雪草、丁香、辛夷挥发油对盐酸氟西汀的体外经皮渗透作用。方法采用改良Franz扩散池,以大鼠离体皮肤为渗透屏障,以氮酮为阳性对照,含30%乙醇的盐酸氟西汀溶液为阴性对照,考察不同体积分数的积雪草、丁香、辛夷挥发油对盐酸氟西汀的经皮渗透影响。通过高效液相色谱法测定药物浓度,计算盐酸氟西汀透皮吸收的累积透过量、透过速率和增渗倍数。结果不同体积分数的挥发油中,以10%积雪草挥发油、3%丁香挥发油、5%辛夷挥发油经皮渗透速率最大,渗透速率分别为74.94、207.55、152.81μg·cm-2·h-1/2。结论 10%积雪草挥发油、3%丁香挥发油、5%辛夷挥发油对盐酸氟西汀经皮吸收具有显著的促进作用。ABSTRACT：OBJECTIVE To study the effects of volatile oils,which were extracted from Centella asiatica,Flos caryophylli, Fols Magnolia,on the transdermal absorption of fluoxetine hydrochloride in vitro .METHODS Using modified Franz diffusion cell and excised male rat skin as transdermal barrier,the effect of volatile oils on permeation degree of fluoxetine hydrochloride from different concentration was compared with 3% azone and negative control group without penetration.The concentration of fluoxetine hydrochloride was determined by HPLC.Accumulative velocity constant and enhancing rate of fluoxetine hydrochlo-ride were calculated.RESULTS The penetration rates （J） of 10% volatile oil in Centella asiatica,3% volatile oil in Flos caryophylli,and 5% volatile oil in Fols Magnolia were 74.94,207.55,152.81 μg.cm^-2.h^-1/2 ,respectively,which were the largest among the different concentration of volatile oils.CONCLUSION The 10% volatile oil of centella asiatica,3% volatile oil in Flos caryophylli,5% volatile oil in Fols Magnolia could enhance penetration of fluoxetine hydrochloride obviously.

关 键 词：积雪草挥发油 丁香挥发油 辛夷挥发油 盐酸氟西汀 经皮吸收 

分 类 号：R94[医药卫生—药剂学]