诊断超声联合微泡促进葡萄糖透皮吸收的研究  

A study of diagnostic ultrasound combined with microbubble in promoting transdermal absorption of glucose

作　　者：曾碧丹[1] 任海红[1] 张文静[1] 罗燕华[1] 陈菲[1] 邱少东[1] 

机构地区：[1]广州医科大学附属第二医院超声科,广东广州510260

出　　处：《广州医科大学学报》2014年第5期13-15,共3页Academic Journal of Guangzhou Medical University

基　　金：广东省医学科研课题资助(项目编号:A2011270)

摘　　要：目的:通过动物实验研究诊断超声联合微泡对葡萄糖透皮吸收的影响。方法:分对照组及实验组。对照组测定空腹血糖及与溶液接触6 min后血糖。实验组测定空腹血糖,并通过输液泵匀速注入SonoVue混悬液,测定与溶液接触6 min后,测实验兔血糖浓度,分析实验组6 min血糖浓度与对照组6min血糖浓度及实验兔空腹血糖浓度差异。结果:实验兔空腹血糖浓度约为(5.33±0.53)mmol/L,对照组6min血糖浓度约为(5.40±0.50)mmol/L,实验组6 min血糖浓度约为(6.15±0.61)mmol/L,实验组6 min血糖浓度与对照组6 min血糖浓度及实验兔空腹血糖浓度差异有统计学意义,(P<0.05)。结论:诊断超声联合微泡可促进葡萄糖透皮吸收,其原理可能与SonoVue增强局部空化作用有关。Objective： To investigate effects of diagnostic ultrasound combined with microbubble on the transdermal absorption of glucose by animal studies. Methods：A control group and an experimental group were included in the study.The control group was measure for levels of fasting blood glucose and blood glucose level at 6 min of dermal contact with glucose solution.The experimental group was measured for fasting blood glucose,then injected with SonoVue suspension by a constant-speed infusion pump before measured for the blood glucose level at 6 min of dermal contact with glucose solution. The differences between the 6 min blood glucose level and the fasting blood glucose was analyzed in the experimental and the control group.Results：Fasting blood glucose level of the experimental rabbits was （5.33±0.53） mmol/L.6 min blood glucose concentration of the control group was （5.40±0.50） mmol/L.6 min blood glucose concentration of the experimental group was about （6.15±0.61） mmol/L.And there were statistical differences in 6 min blood glucose levels between the experimental group and the control group,and between 6 min blood glucose levels and the fasting blood glucose level in either group of rabbits （ P〈0. 05 ） . Conclusion：Diagnostic ultrasound combined with microbubble can promote transdermal absorption of glucose. The underlying mechanism may be associated with the effects of SonoVue enhanced local cavitation.

关 键 词：血糖 超声 SONOVUE 透皮吸收 

分 类 号：TQ423.9[化学工程]