新疆哈萨克族高血压患者外周血淋巴细胞Kv1.3钾离子通道蛋白与左心室肥厚相关  

The relationship between the expression of volgate-gated potassium channel Kv1.3 from plasma lymphocytes and the risk of left ventricular hypertrophy in Kazakh hypertensive patients

作　　者：李晖[1] 李东泽[2] 张源明[3] 高翠荣[4] 王俊华[5] 李鲁[6] 

机构地区：[1]新疆医科大学第一附属医院VIP内科三病区,新疆乌鲁木齐830054 [2]四川大学华西医院心内科 [3]新疆医科大学第一附属医院心脏中心 [4]新疆医科大学第一附属医院风湿科 [5]新疆医科大学第一附属医院临床研究院 [6]新疆医科大学第一附属医院医学检验中心

出　　处：《中华高血压杂志》2015年第4期354-358,共5页Chinese Journal of Hypertension

基　　金：国家自然科学基金项目(81160039)

摘　　要：目的研究淋巴细胞Kv1.3钾离子通道蛋白与新疆哈萨克族高血压患者左心室肥厚（LVH）的关系。方法选取2010年01月至2012年12在新疆医科大学第一附属医院心脏中心住院,未经降压药物治疗的新疆哈萨克族高血压患者100例（男48例,女52例）,年龄（55±14）岁。行心脏彩色多普勒超声检查和淋巴细胞Kv1.3钾离子通道蛋白测定,根据左心室质量指数（LVMI）分为LVH组和非LVH组。Pearson相关分析和多元线性回归分析淋巴细胞Kv1.3钾离子通道蛋白与高血压LVH的相关性。结果 LVH组淋巴细胞Kv1.3钾离子通道蛋白高于非LVH组（P〈0.01）。淋巴细胞Kv1.3钾离子通道蛋白预测LVH最佳临床分界点为7.462×100,敏感度为68.2%,特异度为98.2%,曲线下面积为0.852（95%CI0.714-0.900,P〈0.01）。淋巴细胞Kv1.3钾离子通道蛋白与室间隔厚度、左心室后壁厚度和LVMI呈正相关（分别为r=0.331、0.291和0.218,均P〈0.01）,且淋巴细胞Kv1.3钾离子通道蛋白为室间隔厚度、左心室后壁厚度和LVMI的独立影响因素（分别为β=0.412、0.512和0.319,均P〈0.01）。结论淋巴细胞Kv1.3钾离子通道蛋白为哈萨克族高血压患者LVH的独立影响因素。Objective To investigate the relationship between the expression of volgate-gated potassium channel Kvl. 3 in plasma lymphocytes and the risk of left ventricular hypertrophy （LVH） in Kazakh hypertensive patients. Methods A total of 100 hypertensive patients 1-48 males and 52 females, mean age- （55±14）years] were included. All study patients underwent eehocardiography examination and had the expression of volgate gated potassium channel Kvl. 3 in plasma lymphocytes measured. Based on left ventricular mass index, all study patients were divided into two groups： the LVH group and the non-LVH group. Pearson correlation and multiple linear regression analyses were used to quantify the relationship between the expression of volgate gated potassium channel Kvl. 3 in plasma lymphocytes and LVH. Results The expression of volgate-gated potassium channel Kvl. 3 in plasma lymphoeytes was higher in the LVH group than in the non-LVH group. Receiver operating characteristic （ROC） curve analysis revealed that the cut off point of the expression of volgate-gated potassium channel Kvl. 3 in plasma lymphocytes fo predicting LVH was 7. 462× 100 with the sensibility of 68.2% and the specificity of 98.2%, and the area under the curve of 0. 852 （95 % CI： 0. 714-0. 900, P〈0.01）. The expression of volgate-gated potassium channel Kvl. 3 in plasma lymphocytes was positively correlated with interventricular septal thickness, left ventrieular posterior wall thickness and left ventricular mass index （ r = 0. 331, 0. 291 and 0. 218, all P〈0.01 ）, respectively. The expression of volgate-gated potassium channel Kv1. 3 in plasma lymphocytes was associated with interventricular septal thickness, left ventrieular posterior wall thickness and left ventricular mass index, respectively （β=0. 412, 0. 512 and 0. 319, P〈0.05）. Conclusions The elevated expression of volgate-gated potassium channel Kv1. 3 in plasma lymphocytes can predict the risk of developing LVH, suggesting a close relationship between active lymphoc

关 键 词：哈萨克族 原发性高血压 淋巴细胞 Kv1.3钾离子通道 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]