中老年人群中血清HER-2水平与代谢综合征的关系  

Association of serum HER-2 level with metabolic syndrome in middle-aged and elderly population

作　　者：秦利[1] 祝凌妃[1] 陆帅[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院内分泌科,上海202150

出　　处：《第二军医大学学报》2015年第5期518-521,共4页Academic Journal of Second Military Medical University

摘　　要：目的探讨中老年人群血清HER-2水平与代谢综合征的关联性。方法研究人群为崇明城桥社区687名中老年人群，其中男性309例，女性378例。血清HER2水平采用ELISA方法检测。代谢综合征定义依据NCEP ATPHI（National Cholesterol Education ProgramAdult Treatment PanelⅢ，NECP ATPIll）亚裔美国人标准。结果在校正相关影响因素后，代澍综合征（＋）组（n=370）血清HER-2水平高于对照组（n=317）[（12．4±2．3）ng／mLVS（8．2±1．6）ng／mL，P〈0．001]。随着代谢综合征组分累加，血清HER-2水平增加（P〈O.001）。校正其他风险因素后，多元logistic回归分析显示第4四分位数血清HEK2值组其代谢综合征发生风险较第1四分位数组增加，其OR值为1．35（95％CI：1．14～2．31，P〈O．001）。结论在中老年人群中血清HER-2水平与代谢综合征发病风险相关，且这种关联性独立于其他代谢综合征的风险因素。Objective To investigate the association of circulating HER-2 level with metabolic syndrome in middle-aged and elderly population. Methods We conducted a population-based cross-sectional study with 687 participants aged 40 years or older from a community in Chongming District, Shanghai, China Serum HER-2 levels were measured using ELISA. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel Ⅲ （NCEP ATP Ⅲ ） criteria for Asian-Americans. Results After adjusting for other influencing factors, we found that the participants with metabolic syndrome （n=370） had significantly higher HER-2 level compared with the control group （n= 317） （[12.4±2.3] ng/mL vs [8. 2±1. 6] ng/mL, P〈0. 001）. The serum HER-2 level increased （P〈0.001） with the accumulation of the metabolic syndrome components. After adjusting for potential risk factors, multiple logistic regression analysis showed that the highest quartile of serum HER-2 was associated with increased risk of metabolic syndrome, with a fully adjusted odds ratio （OR） of 1.35 （95% confidence interval [CI] ： 1.14-2.31）, P〈0. 001）. Conclusion Serum HER-2 is independently associated with metabolic syndrome in middle-aged and elderly Chinese in this study.

关 键 词：原癌基因 HER-2 代谢综合征 中年人 老年人 

分 类 号：R589[医药卫生—内分泌]