蛋白聚糖诱导小鼠关节炎模型的研究进展  

Proteoglycan-induced arthritis model in mice:research progress

作　　者：童文文[1] 李甲[1] 徐卫东[1] 

机构地区：[1]第二军医大学长海医院关节骨病外科,上海200433

出　　处：《第二军医大学学报》2015年第5期530-535,共6页Academic Journal of Second Military Medical University

摘　　要：蛋白聚糖诱导的小鼠关节炎模型(PGIA)是由人类关节软骨来源的蛋白聚糖免疫BALB/c小鼠或C3H小鼠的某些亚系而产生的系统性自身免疫性脊柱关节炎小鼠模型。该模型是目前唯一侵犯中轴骨系统的系统性自身免疫小鼠模型,已成为脊柱关节炎动物模型的研究热点。本文旨在通过回顾国内外PGIA相关研究文献,对普遍关注的PGIA动物模型的诱导、表型鉴定、免疫学特性及骨化相关信号通路等进行综述,为脊柱关节炎动物模型研究提供理论基础。Proteoglycan-induced arthritis （PGIA） is a unique systemic autoimmune disease model of spondyloarthritis （SPA） induced by intraperitoneal immunization of either BALB/c or certain C3H colonies with cartilage proteoglycan. This model is currently the only systemic autoimmune mice model with axial skeleton manifestation, which has become a focus of study in SpA modeling. Here in this review we summarize the methods of animal model building, phenotype identification, immunological characteristics and pathways involved in bone remodeling of PGIA based on previous studies, hoping to provide references for study on SpA animal model.

关 键 词：脊柱关节炎 蛋白聚糖类 动物模型 小鼠 免疫 

分 类 号：R684.3[医药卫生—骨科学] R-332[医药卫生—外科学]