布拉氏酵母菌散对轮状病毒肠炎患儿肠道微生态的影响  

Influence of Saccharomyces boulardii powder on intestinal microecology of children with rotavirus enteritis

作　　者：蒋丽芳[1] 魏洪平[1] 吴莉萍[1] 吴敏[2] 

机构地区：[1]义乌市中心医院儿科,浙江义乌322000 [2]义乌市中心医院药剂科,浙江义乌322000

出　　处：《中国微生态学杂志》2015年第5期558-560,共3页Chinese Journal of Microecology

摘　　要：目的观察布拉氏酵母菌散对轮状病毒肠炎患儿肠道微生态的影响。方法采用前瞻性随机对照临床研究方法,将90例轮状病毒肠炎患儿分为观察组和对照组,对照组采用补液及抗病毒等常规治疗,观察组采用常规治疗的基础上加用布拉氏酵母菌散口服,在治疗前、治疗后第8天及治愈后1个月应用实时荧光定量PCR法对粪便标本中双歧杆菌、肠杆菌、乳杆菌的数量进行检测。结果治疗后观察组双歧杆菌、乳杆菌数量高于治疗前(P<0.01,P<0.05),且观察组两类细菌数量均高于对照组(P<0.05)。治疗后两组肠杆菌数量均低于治疗前(P<0.01,P<0.05),且观察组肠杆菌数量低于对照组(P<0.05)。治愈后1个月,三类菌群在两组间比较差异无统计学意义(P>0.05)。结论布拉氏酵母菌散可改善轮状病毒肠炎患儿肠道微生态,且无长期不良影响。Objective To investigate the effect of Saccharomyces boulardii powder on intestinal microecology in children with rotavirus enteritis. Methods A prospective randomized controlled clinical research was conducted. 90 children with rotavirus enteritis were divided into observation group or control group. The children in control group were given common treatment such as infusion, anti-virus therapy etc; the children in observation group were additionally given Saccharomyces boulardii powder. Before treatment, at Day 8 of treatment and 1 month after cure, the numbers of Bifidobacterium, Lactobacillus and Enterobacterium in feces were detected by Real time PCR. Results The numbers of Bifidobacterium and Lactobacillu in observation group increased significantly after treatment （P 〈0. 01 or P 〈0. 05）, and the increasing rate in observation group was much higher than that in con- trol group （P 〈 0. 05）. After treatment, the numbers of Enterobacterium in both group were obviously less than that of before treatment （P 〈 0.01 or P 〈 0.05 ） , and the declining rate in observation group was much higher than that in control group （ P 〈 0. 05 ）. One month after cure, there were no statistically differences in the three bacterial species between the two groups （ P 〉 0.05 ）. Conclusion Saccharomyces boulardii powder can improve the intesti- nal microecology in children with rotavirus enteritis with no long-term adverse effects.

关 键 词：布拉氏酵母菌散 轮状病毒肠炎 肠道微生态 

分 类 号：R725.1[医药卫生—儿科]