早产儿早期微生态干预的临床观察  

Clinical observation of early microecological treatment on premature infants

作　　者：乔木[1] 张丽静[1] 邱锐琴[1] 杜志云[1] 李宝琪[1] 姚文秀[1] 

机构地区：[1]河北省秦皇岛市第一医院新生儿科,河北秦皇岛066000

出　　处：《河北医科大学学报》2015年第5期532-535,共4页Journal of Hebei Medical University

摘　　要：目的探讨早期微生态干预对早产儿的临床应用价值。方法将符合条件的早产儿150例随机分为对照组和治疗组,对照组给予常规治疗,治疗组在此基础上给予口服双歧杆菌乳杆菌三联活菌片治疗,0.5g/次,3次/d,对治疗效果进行对比分析。结果与对照组相比,治疗组喂养不耐受发生率低(χ2=5.042,P<0.05),达全胃肠喂养所需时间早(t=2.058,P<0.05),腹泻发病率下降(χ2=4.127,P<0.05),恢复出生体质量时间短(t=2.308,P<0.01),体质量增长速度快(t=2.698,P<0.05),院内感染发生率降低(χ2=3.857,P<0.05),住院时间缩短(t=4.469,P<0.05)。效益成本比率为37.55∶1,且无益生菌相关性败血症发生。结论早产儿早期补充微生态制剂金双歧,不但可以改善早产儿喂养、促进早产儿生长发育,还可以降低院内感染发生,同时具有较大的经济学价值,值得临床推广。Objective To explore the clinical value of early microecologocal treatment in premature infants.Methods One hundred and fifty premature infants were randomly divided into two groups,treatment group（n=75）and control group（n=75）.Patients of both groups were subjected to routine treatments.Besides,patients of the treatment group were given live combined bifidobacterium and lactobacillus tablets,0.5g,three time a day.Results Compared with control group,treatment group showed the lower incidence of feeding intolerance（χ2=5.042,P〈0.05）,earlier feeding recovery birth body mass（t=2.058,P〈0.05）,lower incidence of diarrhea（χ2=4.127,P〈0.05）,birth body mass growing faster（t=2.308,P〈0.01）,body mass of fast growth（t=2.698,P〈0.05）.The treatment group had the lower incidence of nosocomial infection（χ2=3.857,P〈0.05）,shorter hospitalization time（t=4.469,P〈0.05）.The benefit cost ratio was37.55∶1.There were no probiotics-related sepsis.Conclusion Early microecological treatment with Golden Bifid can not only improve the premature infant feeding and growth,but also reduce the incidence of infection-related disease.The treatment has great value of economics,which worths clinical promotion.

关 键 词：婴儿 早产 益生菌 费用效益分析 

分 类 号：R722.6[医药卫生—儿科]