新型SGLT1/2双靶点抑制剂sotagliflozin  

A new dual sodium-dependent glucose transporter 1/2 inhibitor: sotagliflozin

作　　者：周植星[1] 耿艳艳[1,2] 崔艳丽[3] 刘巍[1] 

机构地区：[1]天津药物研究院天津市新药设计与发现重点实验室,天津300193 [2]天津医科大学,天津300070 [3]天津药物研究院医药信息中心,天津300193

出　　处：《现代药物与临床》2015年第4期465-469,共5页Drugs & Clinic

基　　金：天津市应用基础与前沿技术研究计划项目(14JCZDJC33500)

摘　　要：钠-葡萄糖共转运蛋白2(SGLT2)抑制剂是一类新兴的治疗糖尿病的药物。近年来,遗传学和药理学研究发现,胃肠道SGLT1蛋白也可能成为一个有治疗前景的药物靶点。SGLT1/SGLT2双靶点抑制剂的开发将为糖尿病的治疗提供另一个非胰岛素依赖的途径。临床研究表明,sotagliflozin可以通过双重抑制SGLT1和SGLT2的作用来降低餐后血糖、升高GLP-1和促进尿糖排出。因此,这些特征使得sotagliflozin在对1型和2型糖尿病的治疗方面具有重要临床意义。The sodium-dependent glucose transporter 2 （SGLT2） inhibitors is an important emerging class for the treatment of diabetes. In recent years, genetic and pharmacology researches have indicated that gastrointestinal SGLT1 inhibitors may also be an appropriate therapeutic target to treat diabetes. Combining SGLT1 and SGLT2 inhibitors in a single molecule would provide complementary insulin-independent mechanisms to treat diabetes. Therefore, sotagliflozin has been developed as a dual inhibitor of SGLT1 and SGLT2. The differentiating clinical features of dual inhibitor of SGLT1 and SGLT2 include a large postprandial glucose reduction, elevation of glucagon-like peptide 1 and modest urinary glucose excretion. These features may have clinical implications for the use of sotagliflozin in the treatment of both type 1 and type 2 diabetes.

关 键 词：钠-葡萄糖共转运蛋白2 钠-葡萄糖共转运蛋白1 抑制剂 糖尿病 SGLT2 SGLT1 

分 类 号：R977[医药卫生—药品]