新生儿持续肺动脉高压诊治  

Diagnosis and treatment of neonatal persistent pulmonary hypertension

作　　者：肖燕燕[1] 韩玲[1] 

机构地区：[1]首都医科大学附属北京安贞医院小儿心脏科,北京100029

出　　处：《中国实用儿科杂志》2015年第6期421-424,共4页Chinese Journal of Practical Pediatrics

摘　　要：新生儿持续肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)是指生后肺血管阻力持续性增高,肺动脉压超过体循环动脉压,使由胎儿型循环过渡至正常"成人"型循环发生障碍,引起心房及(或)动脉导管水平血液的右向左分流,临床出现严重低氧血症等症状。此病病因复杂,病死率高,是导致新生儿死亡的主要原因之一。PPHN的治疗目的是降低肺动脉压力,维持体循环压力,纠正右向左分流,改善血氧饱和度。2003年全国新生儿学组制订了PPHN的诊治常规,使对该病的诊治得到统一的认识。本文主要论述PPHN的发病机制及治疗进展。Neonatal persistent pulmonary hypertension （persis- tent pulmonary hypertension of the newborn, PPHN） refers to the continuous increasing status of pulmonary vascular resis- tance after birth and the pulmonary artery pressure exceeds systemic arterial pressure.The fetal circulation type can not transit to the normal adult type, causing right to left shunt atthe atrial and / or PDA blood level, as well as clinical symp- toms such as severe hypoxemia.The pathogenesis of PPHN is complex, which can lead to high mortality and is one of the leading causes of neonatal death.The treatment for PPHN aims to reduce pulmonary artery pressure, maintain systemic pres- sure, correct the right to left shunt and improve blood oxygen saturation.In 2003, the National Neonatology Group organized a conventional diagnosis and treatment principle of PPHN to get unified understanding of the disease.In this article, the re- cent advances of the pathogenesis and treatment of the disease are summarized.

关 键 词：新生儿 持续肺动脉高压 

分 类 号：R72[医药卫生—儿科]