整块切除在甲状旁腺癌治疗中的临床意义  

THE SIGNIFICANCE OF ENBLOC RESECTION IN THE TREATMENT OF PARATHYROID CARCINOMA

作　　者：吴鑫[1] 刘臻[1] 孙韶龙[1] 孟祥鹏[1] 姚威[1] 张鑫[1] 王宝胜[1] 

机构地区：[1]中国医科大学附属盛京医院胰腺乳腺外科,辽宁省沈阳市110004

出　　处：《中国煤炭工业医学杂志》2015年第5期689-692,共4页Chinese Journal of Coal Industry Medicine

基　　金：国家自然科学资金项目(NO:81072182)

摘　　要：目的探讨整块切除在甲状旁腺癌(PC)治疗中的临床意义。方法回顾分析该院1998年3月—2014年10月甲状旁腺癌手术患者22例,其中行简单PC切除10例,行整块切除12例(包括甲状旁腺癌及侵袭组织同侧甲状腺叶峡部及同侧中央区淋巴结),术后病理证实均为甲状旁腺癌。比较二组术后血清钙、甲状旁腺激素(PTH)及术后复发情况等。结果整块切除的患者术后复发1例,简单PC切除的患者复发8例,整块切除组的复发率较简单PC切除组明显降低(P<0.05);二者术后血钙、甲状旁腺素比较差异无统计学意义(P>0.05)。结论甲状旁腺癌患者手术治疗是唯一有效的方法,整块切除能够显著降低术后的复发率。Objective To evaluate the significance of enbloc resection in the treatment of parathyroid carcinoma （PC）. Methods A retrospective analysis of 18 cases of parathyroid carcinoma was performed in our hospital from March 1998 to October 2014. The treatment group（n = 12 ） were received enbloc resection （the parathyroid carcinoma and adhension tissues, resection of the ipsilateral thyroid lobe together with the isthmus and lymphodectomy of the central compartment of the neck）, while the control group （n = 10） received the simple PC resection. All cases were diagnosed by routine histopatbology. Serum calcium, parathyroid hormones and recurrence were observed. Results The recurrence of the treatment group was one case, the control group eight cases. The recurrence rate was significantly reduced between a simple excision of recurrent eight cases and enbloc resection （P〈0.05） ; Both postoperative serum calcium and parathyroid hormone were no significant difference（P〉0.05）. Conclusion Parathyroid carcinoma is a rare tumor, surgery is the only effective treatment. Enbloc resection surgery can reduce the recurrence rate.

关 键 词：整块切除 甲状旁腺癌 原发性甲状旁腺功能亢进 甲状旁腺激素 

分 类 号：R736.2[医药卫生—肿瘤]