小剂量氨茶碱口服联合呼吸功能训练治疗慢性阻塞性肺疾病的疗效评价  

EVALUATION OF THE CLINICAL EFFICACY OF LOW-DOSE ORAL THEOPHYLLINE JOINT TRAINING IN RESPIRATORY FUNCTION IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：李乃庆 王笑歌[2] 

机构地区：[1]柳铁中心医院呼吸内科,广西柳州市545007 [2]中国医科大学附属第四医院

出　　处：《中国煤炭工业医学杂志》2015年第5期699-703,共5页Chinese Journal of Coal Industry Medicine

基　　金：国家科技支撑计划课题(2007BAI24B04)

摘　　要：目的探讨小剂量氨茶碱口服联合呼吸功能训练治疗慢性阻塞性肺疾病(COPD)的疗效。方法将72例COPD患者按照治疗方式分为对照组(n=35)与观察组(n=37),二组均给予化痰、止咳、吸氧以及抗感染等干预。对照组在此基础上采用小剂量氨茶碱治疗,观察组在对照组治疗的基础上联合呼吸功能训练。比较二组临床疗效、治疗前后肺功能改变情况,治疗前后MRC、ADL能力评分及6MWD变化,治疗前后SGRQ评分及治疗前后血清TNF-α及MCP-1水平变化。结果 1观察组临床总有效率为91.43%,显著高于对照组(68.57%)(P<0.05);2对照组治疗前后肺功能指标(FEV1、FEV1%及FVC)水平差异均无统计学意义(P>0.05),但观察组治疗后上述指标水平均显著大于治疗前及对照组治疗后(P<0.05);3二组治疗后MRC评分均显著治疗前,二组治疗后ADL评分及6MWD均显著大于治疗前,且二组治疗后MRC、ADL能力评分及6MWD差异均具有统计学意义(P<0.05);4二组治疗后SGRQ评分量表各维度评分均显著低于治疗前(P<0.05,P<0.01),且观察组治疗后各维度评分均显著低于对照组治疗后(P<0.05);5二组治疗后血清TNF-α及MCP-1水平均显著小于治疗前(P<0.05,P<0.01),且观察组治疗后血清上述指标水平均显著小于对照组治疗后(P<0.05)。结论小剂量氨茶碱口服联合呼吸功能训练治疗慢性阻塞性肺疾病(COPD)的疗效显著,可有效提高患者生活质量及改善患者肺功能,应在临床上进行推广及应用。Objective To investigate the clinical efficacy of low- dose oral Theophylline joint training in respiratory function for treatment of chronic obstructive pulmonary disease （COPD）. Methods A total of 72 cases of COPD patients were randomly divided into control group（n = 35） and observation group （n = 37） according to the method of treating. Both groups were given phlegm, cough, oxygen and antiinfection intervention. The control group was given small dose Theophylline treatment on the basis of the traditional treatment, and the observation group was given training in respiratory function on the basis of the control group. Clinical efficacy, changes in lung function before and after treatment were observed, and then MRC, ADL ability to score and 6MWD change, serum TNF- a and MCP - 1 levels and SGRQ scores before and after treatment were also compared. Results Clinical total effective rate in the observation group was 91.43%, significantly higher than the control group （68.57% ） （P 〈0.05）. Before and after treatment, pulmonary function of the control group （FEV1, FEV1% and FVC） level differences were no statistically significant （P〉0.05）, but pulmonary function of the observation group was significantly higher than the before treatment and than the control group after treatment （P 〈0.05）. MRC score, MRC, ADL ability score and 6MWD after treatment were significantly differences comparison before treatment, and there were statistically significant in the indexs （P〈0.05） after treatment between the two groups. The dimensions scores of SGRQ Rating Scale were significantly lower than before treatment in the two groups （P〈0.05, P〈0.01）, and each dimension scores in the observation group after treatment were significantly lower than in the control group （P〈0.05）. After treatment, serum TNF- a and MCP - 1 levels were significantly lower than before treatment （P〈0.05, P〈0.01）, and they were significantly lower in observation group than the control group （P�

关 键 词：慢性阻塞性肺疾病 氨茶碱 呼吸功能训练 生活质量 

分 类 号：R563[医药卫生—呼吸系统]