44例聚明胶肽注射液不良反应的文献分析  

Literature Analysis of 44 Cases of Adverse Drug Reactions Induced by Polygeline Injection

作　　者：陈海涛[1] 张临宏 昝旺[2] 

机构地区：[1]双流县妇幼保健院,四川双流610200 [2]成都医学院,四川成都610083

出　　处：《中国药物警戒》2015年第5期296-298,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的通过对聚明胶肽注射液致不良反应文献的病例进行分析,探讨其引起不良反应的规律和原因,为临床合理用药提供参考。方法检索中国期刊全文数据库和万方数据库所载的聚明胶肽不良反应文献,对26篇目标文献所报道的44例病例报告进行统计分析。结果聚明胶肽注射液所致不良反应多数为速发型,91%的个案发生在30 min内;聚明胶肽致不良反应累及多个系统-器官,其中以全身性损害(62.50%)和心血管系统损害(10.94%)为主,过敏性休克和严重过敏样反应突出,同时也有新的不良反应出现。结论临床应重视聚明胶肽注射液的不良反应,加强用药监测,确保用药安全。Objective Through analyzing adverse drug reaction cases of polygeline injection to explore the regularity and cause of adverse drug reactions, provide reference for clinical rational drug use. Methods By retrieving CNKI database and Wanfang database, 44 cases of polygeline injection ADRs reported from 26 literatures were analyzed. Results Most of the ADRs are immediate response type, 91% cases happened within 30 mins, which involv multiple systems and organs including systemic lesions（62.50%） and cardiovascular lesions（10.94%）. Allergic shock and severe anaphylactoid reactions are more obvious. At the same time, new ADRs are found in 44 cases. Conclusion More at tention should be paid to the ADRs of polygeline injection and the monitoring of medication should also be strengthened to ensure the safe medication.

关 键 词：聚明胶肽注射液 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学] R973.5[医药卫生—药学]