地佐辛术前给药对全身麻醉患者苏醒期躁动和应激反应的影响  

Impact of pre-operative administration of dezocine on emergence agitation and stress response for patients under general anesthesia

作　　者：李文兵[1] 李安学[1] 蔡云亮[1] 朱红[1] 

机构地区：[1]深圳市龙岗区人民医院麻醉科,深圳518172

出　　处：《中国当代医药》2015年第14期105-107,共3页China Modern Medicine

摘　　要：目的分析地佐辛术前给药对全身麻醉患者苏醒期躁动和应激反应的影响。方法随机抽取本院2012年3月-2014年3月收治的择期接受腹腔镜手术治疗的80例患者作为研究对象,按照随机对照法将其分为对照组与观察组,每组40例。观察组给予地佐辛术前给药,对照组术前给予生理盐水,采取躁动评分及镇静评分量表评估两组患者苏醒期躁动及应激反应发生情况,记录患者的苏醒时间。结果观察组躁动评级Ⅰ级38例,Ⅱ级2例,躁动发生率为5.0%,明显低于对照组的35.0%（P〈0.05）。观察组的苏醒时间为（10.2±2.5）min,拔管时间为（13.2±3.4）min,均短于对照组,且观察组的镇静评分为（2.7±0.2）分,明显高于对照组,疼痛评分为（1.4±0.3）分,显著低于对照组（P〈0.05）。拔管时,观察组的MAP为（86.0±13.3）mm Hg,血压稳定情况明显优于对照组,且其心率为（78.0±11.3）/min,稳定情况优于对照组（P〈0.05）。结论采用地佐辛术前镇痛处理方案可降低拔管期患者躁动发生率,降低术后不良反应发生率,镇痛效果佳,安全性高,值得推广应用。Objective To analyze the impact of pre-operative administration of dezocine on emergence agitation and stress response for patients under general anesthesia. Methods 80 patients received selective laparoscopic surgery admitted into our hospital from March 2012 to March 2014 were randomly selected as research subjects.They were randomly divided into control group （n=40） and observation group （n=40） according to the randomized control method. Observation group was given pre-operative dezocine,and control group was given saline before surgery.Sedation and agitation score scale was applied to evaluate condition of emergence agitation and stress response in two groups,and patients’ recovery time was recorded. Results In observation group,38 patients were rated agitation level Ⅰ,and 2 patients were rated level II.The incidence rate of agitation （5.0%） was significantly lower than that of in control group （35.0%） （P〈0.05）;the emergence time in observation group [ （10.2±2.5） min]and extubating time [ （13.2±3.4） min] was shorter than that of control group respectively.Sedation score in observation group [（2.7±0.2） points] was significantly higher than that in control group.Pain score in observation group [ （1.4±0.3） points] was significantly lower than that in control group （P〈0.05）.Upon extubating,MAP in observation group was （86.0±13.3） mm Hg,and the blood pressure stability was significantly better than that in control group ahile the heart rate in observation group was （78.0±11.3） times every minute,and the stability of heart rate was also better than that in control group （P〈0.05）. Conclusion Pre-operative analgesia treatment scheme of dezocine before surgery helps reduce the incidence rate of agitation during extubating period in patients and lower the incidence rate of adverse effect.It has a favorable effect of analgesia and high safety, which is worthy of promotion and application.

关 键 词：地佐辛 麻醉 躁动 应激反应 不良反应 

分 类 号：R614.24[医药卫生—麻醉学]